7z8z

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'''Unreleased structure'''
 
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The entry 7z8z is ON HOLD until Paper Publication
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==Crystal structure of the MEILB2-BRME1 2:2 core complex==
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<StructureSection load='7z8z' size='340' side='right'caption='[[7z8z]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7z8z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z8Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z8Z FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z8z OCA], [https://pdbe.org/7z8z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z8z RCSB], [https://www.ebi.ac.uk/pdbsum/7z8z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z8z ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HSF2B_MOUSE HSF2B_MOUSE] Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with BRCA2 and its recruitment during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility (PubMed:31242413, PubMed:32345962, PubMed:32463460, PubMed:30760716). Required for proper recombinase recruitment in female meiosis (PubMed:30760716, PubMed:32845237). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (PubMed:23707421). May be involved in modulating HSF2 activation in testis (By similarity).[UniProtKB:O75031]<ref>PMID:23707421</ref> <ref>PMID:30760716</ref> <ref>PMID:31242413</ref> <ref>PMID:32345962</ref> <ref>PMID:32463460</ref> <ref>PMID:32845237</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Davies OR]]
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[[Category: Gurusaran M]]

Revision as of 14:34, 20 September 2023

Crystal structure of the MEILB2-BRME1 2:2 core complex

PDB ID 7z8z

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OCA

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