1emu
From Proteopedia
(New page: 200px<br /> <applet load="1emu" size="450" color="white" frame="true" align="right" spinBox="true" caption="1emu, resolution 1.90Å" /> '''STRUCTURE OF THE AX...) |
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| - | [[Image:1emu. | + | [[Image:1emu.jpg|left|200px]]<br /><applet load="1emu" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="1emu, resolution 1.90Å" /> | caption="1emu, resolution 1.90Å" /> | ||
'''STRUCTURE OF THE AXIN RGS-HOMOLOGOUS DOMAIN IN COMPLEX WITH A SAMP REPEAT FROM APC'''<br /> | '''STRUCTURE OF THE AXIN RGS-HOMOLOGOUS DOMAIN IN COMPLEX WITH A SAMP REPEAT FROM APC'''<br /> | ||
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==Disease== | ==Disease== | ||
| - | Known diseases associated with this structure: Adenoma, periampullary OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id= | + | Known diseases associated with this structure: Adenoma, periampullary OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=611731 611731]], Adenomatous polyposis coli OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=611731 611731]], Brain tumor-polyposis syndrome 2 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=611731 611731]], Caudal duplication anomaly OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603816 603816]], Colorectal cancer, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=611731 611731]], Desmoid disease, hereditary OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=611731 611731]], Gardner syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=611731 611731]], Gastric cancer, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=611731 611731]], Hepatoblastoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=611731 611731]], Hepatocellular carcinoma, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603816 603816]] |
==About this Structure== | ==About this Structure== | ||
| - | 1EMU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with GOL as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1EMU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMU OCA]. |
==Reference== | ==Reference== | ||
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[[Category: rgs domain]] | [[Category: rgs domain]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:44:13 2008'' |
Revision as of 13:44, 15 February 2008
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STRUCTURE OF THE AXIN RGS-HOMOLOGOUS DOMAIN IN COMPLEX WITH A SAMP REPEAT FROM APC
Contents |
Overview
Axin and the adenomatous polyposis coli (APC) tumor suppressor protein are, components of the Wnt/Wingless growth factor signaling pathway. In the, absence of Wnt signal, Axin and APC regulate cytoplasmic levels of the, proto-oncogene beta-catenin through the formation of a large complex, containing these three proteins, glycogen synthase kinase 3beta (GSK3beta), and several other proteins. Both Axin and APC are known to be critical for, beta-catenin regulation, and truncations in APC that eliminate the, Axin-binding site result in human cancers. A protease-resistant domain of, Axin that contains the APC-binding site is a member of the regulators of, G-protein signaling (RGS) superfamily. The crystal structures of this, domain alone and in complex with an Axin-binding sequence from APC reveal, that the Axin-APC interaction occurs at a conserved groove on a face of, the protein that is distinct from the G-protein interface of classical RGS, proteins. The molecular interactions observed in the Axin-APC complex, provide a rationale for the evolutionary conservation seen in both, proteins.
Disease
Known diseases associated with this structure: Adenoma, periampullary OMIM:[611731], Adenomatous polyposis coli OMIM:[611731], Brain tumor-polyposis syndrome 2 OMIM:[611731], Caudal duplication anomaly OMIM:[603816], Colorectal cancer, somatic OMIM:[611731], Desmoid disease, hereditary OMIM:[611731], Gardner syndrome OMIM:[611731], Gastric cancer, somatic OMIM:[611731], Hepatoblastoma OMIM:[611731], Hepatocellular carcinoma, somatic OMIM:[603816]
About this Structure
1EMU is a Protein complex structure of sequences from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Structural basis of the Axin-adenomatous polyposis coli interaction., Spink KE, Polakis P, Weis WI, EMBO J. 2000 May 15;19(10):2270-9. PMID:10811618
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