7tql

==CryoEM structure of the human 40S small ribosomal subunit in complex with translation initiation factors eIF1A and eIF5B.==

<StructureSection load='7tql' size='340' side='right'caption='[[7tql]], [[Resolution|resolution]] 3.40&Aring;' scene=''>

<table><tr><td colspan='2'>[[7tql]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TQL FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tql OCA], [https://pdbe.org/7tql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tql RCSB], [https://www.ebi.ac.uk/pdbsum/7tql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tql ProSAT]</span></td></tr>

== Function ==

[[https://www.uniprot.org/uniprot/IF2P_HUMAN IF2P_HUMAN]] Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes.[UniProtKB:P39730]

[[Category: Homo sapiens]]

[[Category: Alvarado C]]

[[Category: Wang J]]