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7f3g

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Current revision (17:08, 29 November 2023) (edit) (undo)
 
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<StructureSection load='7f3g' size='340' side='right'caption='[[7f3g]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='7f3g' size='340' side='right'caption='[[7f3g]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7f3g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F3G FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7f3g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F3G FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RXT:(3R)-3-CYCLOPENTYL-3-[4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL]PROPANENITRILE'>RXT</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DCLK1, DCAMKL1, DCDC3A, KIAA0369 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RXT:(3R)-3-CYCLOPENTYL-3-[4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL]PROPANENITRILE'>RXT</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f3g OCA], [https://pdbe.org/7f3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f3g RCSB], [https://www.ebi.ac.uk/pdbsum/7f3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f3g ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f3g OCA], [https://pdbe.org/7f3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f3g RCSB], [https://www.ebi.ac.uk/pdbsum/7f3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f3g ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/DCLK1_HUMAN DCLK1_HUMAN]] Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.
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[https://www.uniprot.org/uniprot/DCLK1_HUMAN DCLK1_HUMAN] Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Jang DM]]
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[[Category: Jang, D M]]
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[[Category: Kim HS]]
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[[Category: Kim, H S]]
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[[Category: Lim HJ]]
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[[Category: Lim, H J]]
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[[Category: Doublecortin-like kinase 1]]
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[[Category: Inhibitor]]
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[[Category: Kinase domain]]
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[[Category: Ruxolitinib]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of DCLK1 kinase domain in complex with ruxolitinib

PDB ID 7f3g

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