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2xrc

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Current revision (10:37, 20 December 2023) (edit) (undo)
 
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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2xrc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XRC FirstGlance]. <br>
<table><tr><td colspan='2'>[[2xrc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XRC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.69&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Complement_factor_I Complement factor I], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.45 3.4.21.45] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrc OCA], [https://pdbe.org/2xrc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xrc RCSB], [https://www.ebi.ac.uk/pdbsum/2xrc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xrc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrc OCA], [https://pdbe.org/2xrc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xrc RCSB], [https://www.ebi.ac.uk/pdbsum/2xrc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xrc ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/CFAI_HUMAN CFAI_HUMAN]] HELLP syndrome;Immunodeficiency with factor I anomaly;De novo thrombotic microangiopathy after kidney transplantation;Atypical hemolytic-uremic syndrome with I factor anomaly;Age-related macular degeneration. Disease susceptibility is associated with variations affecting the gene represented in this entry. Other genes may play a role in modifying the phenotype. The disease is caused by mutations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/CFAI_HUMAN CFAI_HUMAN] HELLP syndrome;Immunodeficiency with factor I anomaly;De novo thrombotic microangiopathy after kidney transplantation;Atypical hemolytic-uremic syndrome with I factor anomaly;Age-related macular degeneration. Disease susceptibility is associated with variations affecting the gene represented in this entry. Other genes may play a role in modifying the phenotype. The disease is caused by mutations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CFAI_HUMAN CFAI_HUMAN]] Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively.
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[https://www.uniprot.org/uniprot/CFAI_HUMAN CFAI_HUMAN] Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Complement factor I]]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Johnson, S]]
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[[Category: Johnson S]]
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[[Category: Lea, S M]]
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[[Category: Lea SM]]
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[[Category: Roversi, P]]
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[[Category: Roversi P]]
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[[Category: Complement system]]
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[[Category: Conglutinogen activating factor]]
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[[Category: Hydrolase]]
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[[Category: Immune system]]
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[[Category: Serine protease]]
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Current revision

Human complement factor I

PDB ID 2xrc

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