GLUT1
From Proteopedia
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== Function == | == Function == | ||
| - | The GLUT1 is an insulin-independent glucose transporter expressed by all cells in the body to maintain adequate baseline glucose uptake. Tissues that express GLUT1 at high concentrations include (but are not limited to): the placenta and fetal tissues, epithelial cells of the retina and mammary gland, and the brain.<ref>PMID:31942129</ref> The GLUT1 transporter works synergistically with other solute carriers in the brain. Astrocytes and endothelial cells of brain capillaries primarily express GLUT1; neurons primarily express [[Glut3]]. GLUT1 has a relatively high Km and is upregulated in times of hypoglycemia in the brain to ensure adequate glucose uptake. [[Glut3]] has a low Km to ensure a steady supply of glucose for neurons even when extracellular glucose concentrations are low.<ref>PMID:32789766</ref> | + | The GLUT1 is an insulin-independent glucose transporter expressed by all cells in the body to maintain adequate baseline glucose uptake. Tissues that express GLUT1 at high concentrations include (but are not limited to): the placenta and fetal tissues, epithelial cells of the retina and mammary gland, and the brain.<ref>PMID:31942129</ref> |
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| + | ===Brain=== | ||
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| + | The GLUT1 transporter works synergistically with other solute carriers in the brain. Astrocytes and endothelial cells of brain capillaries primarily express GLUT1; neurons primarily express [[Glut3]]. GLUT1 has a relatively high Km and is upregulated in times of hypoglycemia in the brain to ensure adequate glucose uptake. [[Glut3]] has a low Km to ensure a steady supply of glucose for neurons even when extracellular glucose concentrations are low.<ref>PMID:32789766</ref> | ||
[[Image:Blood-brain_barrier.png]] | [[Image:Blood-brain_barrier.png]] | ||
Revision as of 16:46, 27 April 2022
Facilitated glucose transporter 1, Solute Carrier Family 2 (Homo sapiens)
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References
- ↑ Pragallapati S, Manyam R. Glucose transporter 1 in health and disease. J Oral Maxillofac Pathol. 2019 Sep-Dec;23(3):443-449. doi:, 10.4103/jomfp.JOMFP_22_18. PMID:31942129 doi:http://dx.doi.org/10.4103/jomfp.JOMFP_22_18
- ↑ Koepsell H. Glucose transporters in brain in health and disease. Pflugers Arch. 2020 Sep;472(9):1299-1343. doi: 10.1007/s00424-020-02441-x. Epub, 2020 Aug 13. PMID:32789766 doi:http://dx.doi.org/10.1007/s00424-020-02441-x
- ↑ Asano T, Katagiri H, Takata K, Lin JL, Ishihara H, Inukai K, Tsukuda K, Kikuchi M, Hirano H, Yazaki Y, et al.. The role of N-glycosylation of GLUT1 for glucose transport activity. J Biol Chem. 1991 Dec 25;266(36):24632-6. PMID:1761560
