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<StructureSection load='2jd7' size='340' side='right' caption='3D structure for ferritin' scene=''>
<StructureSection load='2jd7' size='340' side='right' caption='3D structure for ferritin' scene=''>
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== Headline text ==
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<head> Ferritin-Iron Storage and Homeostasis Protein
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Ferritin-Iron Storage and Homeostasis Protein
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== Background ==
== Background ==
Discovered in 1937 by French scientist Laufberger, ferritin was first detected in horse spleen and a few years later in humans <ref name="Wang-2010">PMID:20304033</ref>. Ferritin is a protein that is responsible for iron storage and iron homeostasis, as well as various physiologic and pathological processes in prokaryotes and eukaryotes. Iron homeostasis is essential to maintaining life because iron can be toxic to DNA and proteins if not properly regulated. If there is an overload of iron, reactive oxygen species can be produced, lipid peroxidation can occur, and there can be damage to DNA. Typically, ferritin presents as a cytosolic protein, but there are also mitochondrial and nuclear forms that have recently been discovered. The most common measurement of ferritin is collected from serum ferritin, which is ferritin stored in red blood cells. Many variations of ferritin exist, as it is presumed that evolutionary adaptations were made in order to allow certain organisms to survive.
Discovered in 1937 by French scientist Laufberger, ferritin was first detected in horse spleen and a few years later in humans <ref name="Wang-2010">PMID:20304033</ref>. Ferritin is a protein that is responsible for iron storage and iron homeostasis, as well as various physiologic and pathological processes in prokaryotes and eukaryotes. Iron homeostasis is essential to maintaining life because iron can be toxic to DNA and proteins if not properly regulated. If there is an overload of iron, reactive oxygen species can be produced, lipid peroxidation can occur, and there can be damage to DNA. Typically, ferritin presents as a cytosolic protein, but there are also mitochondrial and nuclear forms that have recently been discovered. The most common measurement of ferritin is collected from serum ferritin, which is ferritin stored in red blood cells. Many variations of ferritin exist, as it is presumed that evolutionary adaptations were made in order to allow certain organisms to survive.

Revision as of 16:52, 29 April 2022

Text To Be Displayed</scene>==Ferritin==

3D structure for ferritin

Drag the structure with the mouse to rotate

References

  1. 1.0 1.1 1.2 1.3 1.4 Wang W, Knovich MA, Coffman LG, Torti FM, Torti SV. Serum ferritin: Past, present and future. Biochim Biophys Acta. 2010 Aug;1800(8):760-9. doi: 10.1016/j.bbagen.2010.03.011. , Epub 2010 Mar 19. PMID:20304033 doi:http://dx.doi.org/10.1016/j.bbagen.2010.03.011
  2. Ferritin. Ferritin - an overview | ScienceDirect Topics. (2018). Retrieved April 18, 2022, from https://www.sciencedirect.com/topics/chemistry/ferritin
  3. Knovich, M. A., Storey, J. A., Coffman, L. G., Torti, S. V., & Torti, F. M. (2009). Ferritin for the clinician. Blood reviews, 23(3), 95-104. https://doi.org/10.1016/j.blre.2008.08.001
  4. 4.0 4.1 Rivera, M. (2017, February 8). Bacterioferritin: Structure, Dynamics, and Protein–Protein Interactions at Play in Iron Storage and Mobilization. ACS Publications. Retrieved April 19, 2022, from https://pubs.acs.org/doi/10.1021/acs.accounts.6b00514
  5. Ebrahimi, K. H., Hagedoorn, P.-L., & Hagen, W. R. (2014, November 24). Unity in the biochemistry of the iron-storage proteins ... Chemistry Reviews. Retrieved April 19, 2022, from https://pubs.acs.org/doi/10.1021/cr5004908
  6. Brown, R. A. M., Richardson, K. L., Kabir, T. D., Trinder, D., Ganss, R., & Leedman, P. J. (1AD, January 1). Altered iron metabolism and impact in cancer biology, metastasis, and Immunology. Frontiers. Retrieved April 21, 2022, from https://www.frontiersin.org/articles/10.3389/fonc.2020.00476/full
  7. Vargas-Vargas, M., & Cortés-Rojo, C. (2020). Ferritin levels and COVID-19. Rev Panam Salud Publica. 2020;44:e72. https://doi.org/10.26633/RPSP.2020.72

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