Ceramidase
From Proteopedia
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'''CerN''' is an enzyme that catalyzes the cleavage of the [https://en.wikipedia.org/wiki/Sphingolipid Sphingolipid] <scene name='91/910024/Ceramide/3'>Ceramide</scene> at the <scene name='91/910024/Ceramide18/1'>N-acyl linkage</scene>, producing <scene name='91/910024/Ceramide/4'>sphingosine and a fatty acid</scene>.<ref name="Okino">PMID:9603946</ref> <ref>PMID:19088069</ref> | '''CerN''' is an enzyme that catalyzes the cleavage of the [https://en.wikipedia.org/wiki/Sphingolipid Sphingolipid] <scene name='91/910024/Ceramide/3'>Ceramide</scene> at the <scene name='91/910024/Ceramide18/1'>N-acyl linkage</scene>, producing <scene name='91/910024/Ceramide/4'>sphingosine and a fatty acid</scene>.<ref name="Okino">PMID:9603946</ref> <ref>PMID:19088069</ref> | ||
| - | + | Refs <ref name="Okino">PMID:9603946</ref>, <ref name="Inoue">PMID:19088069</ref> , <ref name="Reverse">PMID:10832092</ref> | |
== Disease == | == Disease == | ||
Revision as of 16:24, 30 April 2022
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References
- ↑ 1.0 1.1 1.2 Okino N, Tani M, Imayama S, Ito M. Purification and characterization of a novel ceramidase from Pseudomonas aeruginosa. J Biol Chem. 1998 Jun 5;273(23):14368-73. PMID:9603946
- ↑ Inoue T, Okino N, Kakuta Y, Hijikata A, Okano H, Goda HM, Tani M, Sueyoshi N, Kambayashi K, Matsumura H, Kai Y, Ito M. Mechanistic insights into the hydrolysis and synthesis of ceramide by neutral ceramidase. J Biol Chem. 2009 Apr 3;284(14):9566-77. Epub 2008 Dec 16. PMID:19088069 doi:10.1074/jbc.M808232200
- ↑ Inoue T, Okino N, Kakuta Y, Hijikata A, Okano H, Goda HM, Tani M, Sueyoshi N, Kambayashi K, Matsumura H, Kai Y, Ito M. Mechanistic insights into the hydrolysis and synthesis of ceramide by neutral ceramidase. J Biol Chem. 2009 Apr 3;284(14):9566-77. Epub 2008 Dec 16. PMID:19088069 doi:10.1074/jbc.M808232200
- ↑ Kita K, Okino N, Ito M. Reverse hydrolysis reaction of a recombinant alkaline ceramidase of Pseudomonas aeruginosa. Biochim Biophys Acta. 2000 May 31;1485(2-3):111-20. doi:, 10.1016/s1388-1981(00)00029-9. PMID:10832092 doi:http://dx.doi.org/10.1016/s1388-1981(00)00029-9
