NKX2.5 Homeodomain
From Proteopedia
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=='''NKX2.5 Homeodomain'''== | =='''NKX2.5 Homeodomain'''== | ||
<StructureSection load='3RKQ' size='340' side='right' caption=''NKX2.5 Homeodomain dimer bound to ANF-242''=''> | <StructureSection load='3RKQ' size='340' side='right' caption=''NKX2.5 Homeodomain dimer bound to ANF-242''=''> | ||
| - | This is a default text for your page '''NKX2.5 Homeodomain'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
| - | You may include any references to papers as in the use of JSmol in Proteopedia <ref>Pradhan, L., Genis, C., Scone, P., Weinberg, E. O., Kasahara, H., & Nam, H. J. (2012). Crystal structure of the human NKX2.5 homeodomain in complex with DNA target. Biochemistry, 51(32), 6312–6319. https://doi.org/10.1021/bi300849c</ref> or to the article describing Jmol <ref>10.1021/bi300849c</ref> to the rescue. | ||
| - | = General Information = | ||
| - | + | = General Information = | |
| + | The transcription factor, NKX2.5 is one of many proteins classified as a homeodomain, and functions to regulate structural development in eukaryotes. These proteins share a characteristic fold containing three alpha-helices. <ref> Gehring WJ, Affolter M, Burglin T. Homeodomain proteins. Annu Rev Biochem. 1994;63:487–526. </ref>. This evolutionarily conserved structure allows homeodomains to locate and bind specific DNA sequences, leading to transcriptional activation or repression. Furthermore, homeodomain transcription factors act on genes associated with the development of anatomical structures in eukaryotes <ref> Bürglin, T. R., & Affolter, M. (2016). Homeodomain proteins: an update. Chromosoma, 125(3), 497–521. https://doi.org/10.1007/s00412-015-0543-8 </ref>. | ||
| + | multiple transcription factors that work in conjunction during cardiogenesis <ref> Olson, E. N. (2006) Gene regulatory networks in the evolution and development of the heart. Science 313, 1922−1927. </ref> <ref> Akazawa H, Komuro I. Cardiac transcription factor Csx/Nkx2–5: Its role in cardiac development and diseases. Pharmacol Ther. 2005;107:252–268. </ref>. | ||
=== Clinical Relevance === | === Clinical Relevance === | ||
Revision as of 04:00, 2 May 2022
NKX2.5 Homeodomain
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References
- ↑ Gehring WJ, Affolter M, Burglin T. Homeodomain proteins. Annu Rev Biochem. 1994;63:487–526.
- ↑ Bürglin, T. R., & Affolter, M. (2016). Homeodomain proteins: an update. Chromosoma, 125(3), 497–521. https://doi.org/10.1007/s00412-015-0543-8
- ↑ Olson, E. N. (2006) Gene regulatory networks in the evolution and development of the heart. Science 313, 1922−1927.
- ↑ Akazawa H, Komuro I. Cardiac transcription factor Csx/Nkx2–5: Its role in cardiac development and diseases. Pharmacol Ther. 2005;107:252–268.
