1es7
From Proteopedia
(New page: 200px<br /> <applet load="1es7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1es7, resolution 2.90Å" /> '''COMPLEX BETWEEN BMP...) |
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| - | [[Image:1es7.gif|left|200px]]<br /> | + | [[Image:1es7.gif|left|200px]]<br /><applet load="1es7" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1es7" size=" | + | |
caption="1es7, resolution 2.90Å" /> | caption="1es7, resolution 2.90Å" /> | ||
'''COMPLEX BETWEEN BMP-2 AND TWO BMP RECEPTOR IA ECTODOMAINS'''<br /> | '''COMPLEX BETWEEN BMP-2 AND TWO BMP RECEPTOR IA ECTODOMAINS'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Bone morphogenetic proteins (BMPs) belong to the large transforming growth | + | Bone morphogenetic proteins (BMPs) belong to the large transforming growth factor-beta (TGF-beta) superfamily of multifunctional cytokines. BMP-2 can induce ectopic bone and cartilage formation in adult vertebrates and is involved in central steps in early embryonal development in animals. Signaling by these cytokines requires binding of two types of transmembrane serine/threonine receptor kinase chains classified as type I and type II. Here we report the crystal structure of human dimeric BMP-2 in complex with two high affinity BMP receptor IA extracellular domains (BRIAec). The receptor chains bind to the 'wrist' epitopes of the BMP-2 dimer and contact both BMP-2 monomers. No contacts exist between the receptor domains. The model reveals the structural basis for discrimination between type I and type II receptors and the variability of receptor-ligand interactions that is seen in BMP-TGF-beta systems. |
==Disease== | ==Disease== | ||
| - | Known diseases associated with this structure: | + | Known diseases associated with this structure: HFE hemochromatosis, modifier of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=112261 112261]], Juvenile polyposis syndrome, infantile form OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601299 601299]], Polyposis syndrome, hereditary mixed, 2 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601299 601299]], Polyposis, juvenile intestinal OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601299 601299]] |
==About this Structure== | ==About this Structure== | ||
| - | 1ES7 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1ES7 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ES7 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Dreyer, M | + | [[Category: Dreyer, M K.]] |
[[Category: Kirsch, T.]] | [[Category: Kirsch, T.]] | ||
[[Category: Sebald, W.]] | [[Category: Sebald, W.]] | ||
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[[Category: three finger toxin fold]] | [[Category: three finger toxin fold]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:30:56 2008'' |
Revision as of 10:30, 21 February 2008
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COMPLEX BETWEEN BMP-2 AND TWO BMP RECEPTOR IA ECTODOMAINS
Contents |
Overview
Bone morphogenetic proteins (BMPs) belong to the large transforming growth factor-beta (TGF-beta) superfamily of multifunctional cytokines. BMP-2 can induce ectopic bone and cartilage formation in adult vertebrates and is involved in central steps in early embryonal development in animals. Signaling by these cytokines requires binding of two types of transmembrane serine/threonine receptor kinase chains classified as type I and type II. Here we report the crystal structure of human dimeric BMP-2 in complex with two high affinity BMP receptor IA extracellular domains (BRIAec). The receptor chains bind to the 'wrist' epitopes of the BMP-2 dimer and contact both BMP-2 monomers. No contacts exist between the receptor domains. The model reveals the structural basis for discrimination between type I and type II receptors and the variability of receptor-ligand interactions that is seen in BMP-TGF-beta systems.
Disease
Known diseases associated with this structure: HFE hemochromatosis, modifier of OMIM:[112261], Juvenile polyposis syndrome, infantile form OMIM:[601299], Polyposis syndrome, hereditary mixed, 2 OMIM:[601299], Polyposis, juvenile intestinal OMIM:[601299]
About this Structure
1ES7 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the BMP-2-BRIA ectodomain complex., Kirsch T, Sebald W, Dreyer MK, Nat Struct Biol. 2000 Jun;7(6):492-6. PMID:10881198
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