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1h1t

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{{STRUCTURE_1h1t| PDB=1h1t | SCENE= }}
{{STRUCTURE_1h1t| PDB=1h1t | SCENE= }}
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'''PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE IN COMPLEX WITH COENZYME A FROM ESCHERICHIA COLI'''
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===PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE IN COMPLEX WITH COENZYME A FROM ESCHERICHIA COLI===
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==Overview==
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Phosphopantetheine adenylyltransferase (PPAT) regulates the key penultimate step in the essential coenzyme A (CoA) biosynthetic pathway. PPAT catalyzes the reversible transfer of an adenylyl group from Mg(2+):ATP to 4'-phosphopantetheine to form 3'-dephospho-CoA (dPCoA) and pyrophosphate. The high-resolution crystal structure of PPAT complexed with CoA has been determined. Remarkably, CoA and the product dPCoA bind to the active site in distinct ways. Although the phosphate moiety within the phosphopantetheine arm overlaps, the pantetheine arm binds to the same pocket in two distinct conformations, and the adenylyl moieties of these two ligands have distinct binding sites. Moreover, the PPAT:CoA crystal structure confirms the asymmetry of binding to the two trimers within the hexameric enzyme. Specifically, the pantetheine arm of CoA bound to one protomer within the asymmetric unit displays the dPCoA-like conformation with the adenylyl moiety disordered, whereas CoA binds the twofold-related protomer in an ordered and unique fashion.
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{{ABSTRACT_PUBMED_12837781}}
==About this Structure==
==About this Structure==
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[[Category: Nucleotidyltransferase]]
[[Category: Nucleotidyltransferase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:18:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:28:44 2008''

Revision as of 03:28, 1 July 2008

Image:1h1t.png

Template:STRUCTURE 1h1t

PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE IN COMPLEX WITH COENZYME A FROM ESCHERICHIA COLI

Template:ABSTRACT PUBMED 12837781

About this Structure

1H1T is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

A novel adenylate binding site confers phosphopantetheine adenylyltransferase interactions with coenzyme A., Izard T, J Bacteriol. 2003 Jul;185(14):4074-80. PMID:12837781

Page seeded by OCA on Tue Jul 1 06:28:44 2008

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