3a5p

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Current revision (08:40, 7 February 2024) (edit) (undo)
 
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<StructureSection load='3a5p' size='340' side='right'caption='[[3a5p]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
<StructureSection load='3a5p' size='340' side='right'caption='[[3a5p]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3a5p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Phypo Phypo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A5P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A5P FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3a5p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Physarum_polycephalum Physarum polycephalum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A5P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A5P FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a5p OCA], [https://pdbe.org/3a5p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a5p RCSB], [https://www.ebi.ac.uk/pdbsum/3a5p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a5p ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a5p OCA], [https://pdbe.org/3a5p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a5p RCSB], [https://www.ebi.ac.uk/pdbsum/3a5p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a5p ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/O60949_PHYPO O60949_PHYPO]
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Physarum polycephalum hemagglutinin I (HA1) is a 104-residue protein that is secreted to extracellular space. The crystal structure of HA1 has a beta-sandwich fold found among lectin structures, such as legume lectins and galectins. Interestingly, the beta-sandwich of HA1 lacks a jelly roll motif and is essentially composed of two simple up-and-down beta-sheets. This up-and-down beta-sheet motif is well conserved in other legume lectin-like proteins derived from animals, plants, bacteria, and viruses. It is more noteworthy that the up-and-down beta-sheet motif includes many residues that make contact with the target carbohydrates. Our NMR data demonstrate that HA1 lacking a jelly roll motif also binds to its target glycopeptide. Taken together, these data show that the up-and-down beta-sheet motif provides a fundamental scaffold for the binding of legume lectin-like proteins to the target carbohydrates, and the structure of HA1 suggests a minimal carbohydrate recognition domain.
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The Structure of Physarum polycephalum Hemagglutinin I Suggests a Minimal Carbohydrate Recognition Domain of Legume Lectin Fold.,Kouno T, Watanabe N, Sakai N, Nakamura T, Nabeshima Y, Morita M, Mizuguchi M, Aizawa T, Demura M, Imanaka T, Tanaka I, Kawano K J Mol Biol. 2010 Nov 20. PMID:21094650<ref>PMID:21094650</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3a5p" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Phypo]]
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[[Category: Physarum polycephalum]]
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[[Category: Kawano, K]]
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[[Category: Kawano K]]
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[[Category: Kouno, T]]
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[[Category: Kouno T]]
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[[Category: Mizuguchi, M]]
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[[Category: Mizuguchi M]]
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[[Category: Nabeshima, Y]]
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[[Category: Nabeshima Y]]
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[[Category: Nakamura, T]]
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[[Category: Nakamura T]]
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[[Category: Sakai, N]]
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[[Category: Sakai N]]
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[[Category: Watanabe, N]]
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[[Category: Watanabe N]]
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[[Category: Lectin]]
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[[Category: Sugar binding protein]]
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Current revision

Crystal structure of hemagglutinin

PDB ID 3a5p

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