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3kz7

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Current revision (16:18, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3kz7' size='340' side='right'caption='[[3kz7]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='3kz7' size='340' side='right'caption='[[3kz7]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3kz7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KZ7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3kz7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KZ7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1pbk|1pbk]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Fkbp25, Fkbp3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kz7 OCA], [https://pdbe.org/3kz7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kz7 RCSB], [https://www.ebi.ac.uk/pdbsum/3kz7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kz7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kz7 OCA], [https://pdbe.org/3kz7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kz7 RCSB], [https://www.ebi.ac.uk/pdbsum/3kz7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kz7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/FKBP3_MOUSE FKBP3_MOUSE]] FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins (By similarity).
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[https://www.uniprot.org/uniprot/FKBP3_MOUSE FKBP3_MOUSE] FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Galat A]]
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[[Category: Galat, A]]
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[[Category: Stura EA]]
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[[Category: Stura, E A]]
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[[Category: Fkpb ppiase rapamycin]]
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[[Category: Isomerase]]
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[[Category: Isomerase-inhibitor complex]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Rotamase]]
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Current revision

C-terminal domain of Murine FKBP25 rapamycin complex

PDB ID 3kz7

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