This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3l21
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='3l21' size='340' side='right'caption='[[3l21]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='3l21' size='340' side='right'caption='[[3l21]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3l21]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3l21]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L21 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand= | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=KPI:(2S)-2-AMINO-6-[(1-HYDROXY-1-OXO-PROPAN-2-YLIDENE)AMINO]HEXANOIC+ACID'>KPI</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | + | ||
| - | + | ||
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l21 OCA], [https://pdbe.org/3l21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l21 RCSB], [https://www.ebi.ac.uk/pdbsum/3l21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l21 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l21 OCA], [https://pdbe.org/3l21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l21 RCSB], [https://www.ebi.ac.uk/pdbsum/3l21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l21 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/DAPA_MYCTU DAPA_MYCTU] Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA) (Probable).<ref>PMID:18062777</ref> | |
==See Also== | ==See Also== | ||
| Line 20: | Line 17: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: 4-hydroxy-tetrahydrodipicolinate synthase]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Devenish, S R]] | ||
| - | [[Category: Evans, G L]] | ||
| - | [[Category: Gerrard, J A]] | ||
| - | [[Category: Jamerson, G B]] | ||
| - | [[Category: Schuldt, L]] | ||
| - | [[Category: Weiss, M S]] | ||
| - | [[Category: Amino-acid biosynthesis]] | ||
| - | [[Category: Dapa]] | ||
| - | [[Category: Dhdp]] | ||
| - | [[Category: Diaminopimelate biosynthesis]] | ||
| - | [[Category: Dihydrodipicolinate synthase]] | ||
| - | [[Category: Dimer]] | ||
| - | [[Category: Lyase]] | ||
| - | [[Category: Lysine biosynthesis]] | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
| - | [[Category: | + | [[Category: Devenish SR]] |
| - | [[Category: | + | [[Category: Evans GL]] |
| - | [[Category: | + | [[Category: Gerrard JA]] |
| + | [[Category: Jamerson GB]] | ||
| + | [[Category: Schuldt L]] | ||
| + | [[Category: Weiss MS]] | ||
Current revision
The crystal structure of a dimeric mutant of dihydrodipicolinate synthase (DAPA, RV2753C) from Mycobacterium Tuberculosis - DHDPS-A204R
| |||||||||||
