1ete
From Proteopedia
(New page: 200px<br /> <applet load="1ete" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ete, resolution 2.2Å" /> '''CRYSTAL STRUCTURE OF...) |
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| - | [[Image:1ete.gif|left|200px]]<br /> | + | [[Image:1ete.gif|left|200px]]<br /><applet load="1ete" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1ete" size=" | + | |
caption="1ete, resolution 2.2Å" /> | caption="1ete, resolution 2.2Å" /> | ||
'''CRYSTAL STRUCTURE OF THE FLT3 LIGAND'''<br /> | '''CRYSTAL STRUCTURE OF THE FLT3 LIGAND'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Human Flt3 ligand (Flt3L) stimulates early hematopoiesis by activating a | + | Human Flt3 ligand (Flt3L) stimulates early hematopoiesis by activating a type III tyrosine kinase receptor on primitive bone marrow stem cells. The crystal structure of soluble Flt3L reveals that it is a homodimer of two short chain alpha-helical bundles. Comparisons of structure-function relationships of Flt3L with the homologous hematopoietic cytokines macrophage colony stimulating factor (MCSF) and stem cell factor (SCF) suggest that they have a common receptor binding mode that is distinct from the paradigm derived from the complex of growth hormone with its receptor. Furthermore, we identify recognition features common to all helical and cystine-knot protein ligands that activate type III tyrosine kinase receptors, and the closely related type V tyrosine kinase receptors. |
==About this Structure== | ==About this Structure== | ||
| - | 1ETE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1ETE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ETE OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Boone, T.]] | [[Category: Boone, T.]] | ||
| - | [[Category: Karplus, P | + | [[Category: Karplus, P A.]] |
| - | [[Category: Savvides, S | + | [[Category: Savvides, S N.]] |
[[Category: ZN]] | [[Category: ZN]] | ||
[[Category: four-helix bundle]] | [[Category: four-helix bundle]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:31:21 2008'' |
Revision as of 10:31, 21 February 2008
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CRYSTAL STRUCTURE OF THE FLT3 LIGAND
Overview
Human Flt3 ligand (Flt3L) stimulates early hematopoiesis by activating a type III tyrosine kinase receptor on primitive bone marrow stem cells. The crystal structure of soluble Flt3L reveals that it is a homodimer of two short chain alpha-helical bundles. Comparisons of structure-function relationships of Flt3L with the homologous hematopoietic cytokines macrophage colony stimulating factor (MCSF) and stem cell factor (SCF) suggest that they have a common receptor binding mode that is distinct from the paradigm derived from the complex of growth hormone with its receptor. Furthermore, we identify recognition features common to all helical and cystine-knot protein ligands that activate type III tyrosine kinase receptors, and the closely related type V tyrosine kinase receptors.
About this Structure
1ETE is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots., Savvides SN, Boone T, Andrew Karplus P, Nat Struct Biol. 2000 Jun;7(6):486-91. PMID:10881197
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