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1h2i

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{{STRUCTURE_1h2i| PDB=1h2i | SCENE= }}
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'''HUMAN RAD52 PROTEIN, N-TERMINAL DOMAIN'''
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===HUMAN RAD52 PROTEIN, N-TERMINAL DOMAIN===
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==Overview==
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In eukaryotic cells, RAD52 protein plays a central role in genetic recombination and DNA repair by (i) promoting the annealing of complementary single-stranded DNA and (ii) stimulation of the RAD51 recombinase. The single-strand annealing domain resides in the N-terminal region of the protein and is highly conserved, whereas the nonconserved RAD51-interaction domain is located in the C-terminal region. An N-terminal fragment of human RAD52 (residues 1-209) has been purified to homogeneity and, similar to the full-size protein (residues 1-418), shown to promote single-strand annealing in vitro. We have determined the crystal structure of this single-strand annealing domain at 2.7 A. The structure reveals an undecameric (11) subunit ring with extensive subunit contacts. A large, positively charged groove runs along the surface of the ring, readily suggesting a mechanism by which RAD52 presents the single strand for reannealing with complementary single-stranded DNA.
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(as it appears on PubMed at http://www.pubmed.gov), where 12370410 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12370410}}
==About this Structure==
==About this Structure==
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[[Category: Dna repair]]
[[Category: Dna repair]]
[[Category: Dna-binding protein]]
[[Category: Dna-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:20:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:31:00 2008''

Revision as of 03:31, 1 July 2008

Image:1h2i.png

Template:STRUCTURE 1h2i

HUMAN RAD52 PROTEIN, N-TERMINAL DOMAIN

Template:ABSTRACT PUBMED 12370410

About this Structure

1H2I is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the single-strand annealing domain of human RAD52 protein., Singleton MR, Wentzell LM, Liu Y, West SC, Wigley DB, Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13492-7. Epub 2002 Oct 7. PMID:12370410

Page seeded by OCA on Tue Jul 1 06:31:00 2008

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