1h2t

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1h2t.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1h2t.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1h2t| PDB=1h2t | SCENE= }}
{{STRUCTURE_1h2t| PDB=1h2t | SCENE= }}
-
'''STRUCTURE OF THE HUMAN NUCLEAR CAP-BINDING-COMPLEX (CBC) IN COMPLEX WITH A CAP ANALOGUE M7GPPPG'''
+
===STRUCTURE OF THE HUMAN NUCLEAR CAP-BINDING-COMPLEX (CBC) IN COMPLEX WITH A CAP ANALOGUE M7GPPPG===
-
==Overview==
+
<!--
-
The heterodimeric nuclear cap-binding complex (CBC) binds to the 5' cap structure of RNAs in the nucleus and plays a central role in their diverse maturation steps. We describe the crystal structure at 2.1 A resolution of human CBC bound to an m(7)GpppG cap analogue. Comparison with the structure of uncomplexed CBC shows that cap binding induces co-operative folding around the dinucleotide of some 50 residues from the N- and C-terminal extensions to the central RNP domain of the small subunit CBP20. The cap-bound conformation of CBP20 is stabilized by an intricate network of interactions both to the ligand and within the subunit, as well as new interactions of the CBP20 N-terminal tail with the large subunit CBP80. Although the structure is very different from that of other known cap-binding proteins, such as the cytoplasmic cap-binding protein eIF4E, specificity for the methylated guanosine again is achieved by sandwiching the base between two aromatic residues, in this case two conserved tyrosines. Implications for the transfer of capped mRNAs to eIF4E, required for translation initiation, are discussed.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12374755}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12374755 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12374755}}
==About this Structure==
==About this Structure==
Line 34: Line 38:
[[Category: Rna-binding]]
[[Category: Rna-binding]]
[[Category: Rnp domain]]
[[Category: Rnp domain]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:21:21 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:31:51 2008''

Revision as of 03:31, 1 July 2008

Image:1h2t.png

Template:STRUCTURE 1h2t

STRUCTURE OF THE HUMAN NUCLEAR CAP-BINDING-COMPLEX (CBC) IN COMPLEX WITH A CAP ANALOGUE M7GPPPG

Template:ABSTRACT PUBMED 12374755

About this Structure

1H2T is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex., Mazza C, Segref A, Mattaj IW, Cusack S, EMBO J. 2002 Oct 15;21(20):5548-57. PMID:12374755

Page seeded by OCA on Tue Jul 1 06:31:51 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1h2t"
Personal tools