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1h30

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{{STRUCTURE_1h30| PDB=1h30 | SCENE= }}
{{STRUCTURE_1h30| PDB=1h30 | SCENE= }}
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'''C-TERMINAL LG DOMAIN PAIR OF HUMAN GAS6'''
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===C-TERMINAL LG DOMAIN PAIR OF HUMAN GAS6===
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==Overview==
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Receptor tyrosine kinases of the Axl family are activated by Gas6, the product of growth arrest-specific gene 6. Gas6-Axl signaling is implicated in cell survival, adhesion, and migration. The receptor-binding site of Gas6 is located within a C-terminal pair of laminin G-like (LG) domains that do not resemble any other receptor tyrosine kinase ligand. We report the crystal structure at 2.2-A resolution of a Gas6 fragment spanning both LG domains (Gas6-LG). The structure reveals a V-shaped arrangement of LG domains strengthened by an interdomain calcium-binding site. LG2 of Gas6-LG contains two unusual features: an alpha-helix cradled by one edge of the LG beta-sandwich and a conspicuous patch of surface-exposed hydrophobic residues. Mutagenesis of some residues in this patch reduces Gas6-LG binding to the extracellular domain of Axl as well as Axl activation in glioblastoma cells, identifying a component of the receptor-binding site of Gas6.
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{{ABSTRACT_PUBMED_12218057}}
==About this Structure==
==About this Structure==
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[[Category: Laminin g-like domain]]
[[Category: Laminin g-like domain]]
[[Category: Vitamin k-dependent protein]]
[[Category: Vitamin k-dependent protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:21:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:32:24 2008''

Revision as of 03:32, 1 July 2008

Image:1h30.png

Template:STRUCTURE 1h30

C-TERMINAL LG DOMAIN PAIR OF HUMAN GAS6

Template:ABSTRACT PUBMED 12218057

About this Structure

1H30 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a C-terminal fragment of growth arrest-specific protein Gas6. Receptor tyrosine kinase activation by laminin G-like domains., Sasaki T, Knyazev PG, Cheburkin Y, Gohring W, Tisi D, Ullrich A, Timpl R, Hohenester E, J Biol Chem. 2002 Nov 15;277(46):44164-70. Epub 2002 Sep 5. PMID:12218057

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