7urw
From Proteopedia
(Difference between revisions)
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==Tetradecameric hub domain of CaMKII beta== | ==Tetradecameric hub domain of CaMKII beta== | ||
| - | <StructureSection load='7urw' size='340' side='right'caption='[[7urw]]' scene=''> | + | <StructureSection load='7urw' size='340' side='right'caption='[[7urw]], [[Resolution|resolution]] 3.11Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7URW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7URW FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7urw]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7URW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7URW FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7urw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7urw OCA], [https://pdbe.org/7urw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7urw RCSB], [https://www.ebi.ac.uk/pdbsum/7urw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7urw ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.11Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7urw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7urw OCA], [https://pdbe.org/7urw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7urw RCSB], [https://www.ebi.ac.uk/pdbsum/7urw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7urw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KCC2B_HUMAN KCC2B_HUMAN] Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.<ref>PMID:16690701</ref> | ||
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| + | ==See Also== | ||
| + | *[[Calcium/calmodulin dependent protein kinase 3D structures|Calcium/calmodulin dependent protein kinase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Garman SC]] | [[Category: Garman SC]] | ||
Current revision
Tetradecameric hub domain of CaMKII beta
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