1h3m

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{{Seed}}
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{{STRUCTURE_1h3m| PDB=1h3m | SCENE= }}
{{STRUCTURE_1h3m| PDB=1h3m | SCENE= }}
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'''STRUCTURE OF 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL SYNTHETASE'''
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===STRUCTURE OF 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL SYNTHETASE===
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==Overview==
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2-C-Methyl-D-erythritol 4-phosphate cytidylyltransferase is an essential enzyme in the mevalonate-independent pathway of isoprenoid biosynthesis. The structure of a tetragonal crystal form has been solved by molecular replacement and refined to 2.4 A resolution. Structure and sequence comparisons suggest that the enzyme is a suitable target for a structure-based approach to the development of novel broad-spectrum antibiotics. However, the absence of ligands in the enzyme active site together with the moderate resolution of the structure indicates that this tetragonal crystal form is inferior to that of a previously reported highly ordered monoclinic form [Richard et al. (2001), Nature Struct. Biol. 8, 641-647].
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(as it appears on PubMed at http://www.pubmed.gov), where 12595740 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12595740}}
==About this Structure==
==About this Structure==
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[[Category: Isoprenoid]]
[[Category: Isoprenoid]]
[[Category: Synthetase]]
[[Category: Synthetase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:23:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:34:13 2008''

Revision as of 03:34, 1 July 2008

Image:1h3m.png

Template:STRUCTURE 1h3m

STRUCTURE OF 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL SYNTHETASE

Template:ABSTRACT PUBMED 12595740

About this Structure

1H3M is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of a tetragonal crystal form of Escherichia coli 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase., Kemp LE, Bond CS, Hunter WN, Acta Crystallogr D Biol Crystallogr. 2003 Mar;59(Pt 3):607-10. Epub 2003, Feb 21. PMID:12595740

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