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1h3p

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{{STRUCTURE_1h3p| PDB=1h3p | SCENE= }}
{{STRUCTURE_1h3p| PDB=1h3p | SCENE= }}
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'''STRUCTURAL CHARACTERISATION OF A MONOCLONAL ANTIBODY SPECIFIC FOR THE PRES1 REGION OF THE HEPATITIS B VIRUS'''
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===STRUCTURAL CHARACTERISATION OF A MONOCLONAL ANTIBODY SPECIFIC FOR THE PRES1 REGION OF THE HEPATITIS B VIRUS===
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==Overview==
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The monoclonal antibody 5a19, raised against the ay serotype of hepatitis B virus, binds to the segment of the preS1 region comprising residues 37-43, which is implicated in attachment of the virus to hepatocytes. The dissociation constant, derived from kinetic studies using surface plasmon resonance techniques, is in the low nanomolar range. The nucleotide sequence of the variable domains has been determined and the corresponding germ-line genes have been identified. The three-dimensional structure of the Fab fragment has been determined by X-ray crystallography to 2.6 A resolution.
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(as it appears on PubMed at http://www.pubmed.gov), where 11749974 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11749974}}
==About this Structure==
==About this Structure==
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[[Category: Antibody fab fragment]]
[[Category: Antibody fab fragment]]
[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:23:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:34:29 2008''

Revision as of 03:34, 1 July 2008

Image:1h3p.png

Template:STRUCTURE 1h3p

STRUCTURAL CHARACTERISATION OF A MONOCLONAL ANTIBODY SPECIFIC FOR THE PRES1 REGION OF THE HEPATITIS B VIRUS

Template:ABSTRACT PUBMED 11749974

About this Structure

1H3P is a Single protein structure of sequence from Mus musculus. This structure supersedes the now removed PDB entry 1gm3. Full crystallographic information is available from OCA.

Reference

Structural and functional characterization of a monoclonal antibody specific for the preS1 region of hepatitis B virus., Pizarro JC, Vulliez-le Normand B, Riottot MM, Budkowska A, Bentley GA, FEBS Lett. 2001 Dec 14;509(3):463-8. PMID:11749974

Page seeded by OCA on Tue Jul 1 06:34:29 2008

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