3nb3

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Current revision (09:59, 14 February 2024) (edit) (undo)
 
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<SX load='3nb3' size='340' side='right' viewer='molstar' caption='[[3nb3]], [[Resolution|resolution]] 19.00&Aring;' scene=''>
<SX load='3nb3' size='340' side='right' viewer='molstar' caption='[[3nb3]], [[Resolution|resolution]] 19.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3nb3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NB3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NB3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3nb3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NB3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NB3 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1qjp|1qjp]], [[2j1n|2j1n]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 19&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nb3 OCA], [https://pdbe.org/3nb3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nb3 RCSB], [https://www.ebi.ac.uk/pdbsum/3nb3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nb3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nb3 OCA], [https://pdbe.org/3nb3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nb3 RCSB], [https://www.ebi.ac.uk/pdbsum/3nb3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nb3 ProSAT]</span></td></tr>
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</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/OMPA_ECOLI OMPA_ECOLI]] Required for the action of colicins K and L and for the stabilization of mating aggregates in conjugation. Serves as a receptor for a number of T-even like phages. Also acts as a porin with low permeability that allows slow penetration of small solutes. [[https://www.uniprot.org/uniprot/OMPC_ECOLI OMPC_ECOLI]] Forms pores that allow passive diffusion of small molecules across the outer membrane.
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[https://www.uniprot.org/uniprot/OMPA_ECOLI OMPA_ECOLI] Required for the action of colicins K and L and for the stabilization of mating aggregates in conjugation. Serves as a receptor for a number of T-even like phages. Also acts as a porin with low permeability that allows slow penetration of small solutes.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Assembly of dsDNA bacteriophage is a precisely programmed process. Potential roles of host cell components in phage assembly haven't been well understood. It was previously reported that two unidentified proteins were present in bacteriophage Sf6 virion (Casjens et al, 2004, J.Mol.Biol. 339, 379-394, Fig. 2A). Using tandem mass spectrometry, we have identified the two proteins as outer membrane proteins (OMPs) OmpA and OmpC from its host Shigella flexneri. The transmission electron cryo-microscopy structure of Sf6 shows significant density at specific sites at the phage capsid inner surface. This density fit well with the characteristic beta-barrel domains of OMPs, thus may be due to the two host proteins. Locations of this density suggest a role in Sf6 morphogenesis reminiscent of phage-encoded cementing proteins. These data indicate a new, OMP-related phage:host linkage, adding to previous knowledge that some lambdoid bacteriophage genomes contain OmpC-like genes that express phage-encoded porins in the lysogenic state.
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The host outer membrane proteins OmpA and OmpC are associated with the Shigella phage Sf6 virion.,Zhao H, Sequeira RD, Galeva NA, Tang L Virology. 2011 Jan 20;409(2):319-27. Epub 2010 Nov 10. PMID:21071053<ref>PMID:21071053</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3nb3" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Porin 3D structures|Porin 3D structures]]
*[[Porin 3D structures|Porin 3D structures]]
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== References ==
 
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<references/>
 
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__TOC__
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[[Category: Escherichia coli]]
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[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Galeva, N A]]
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[[Category: Galeva NA]]
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[[Category: Sequeira, R D]]
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[[Category: Sequeira RD]]
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[[Category: Tang, L]]
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[[Category: Tang L]]
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[[Category: Zhao, H]]
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[[Category: Zhao H]]
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[[Category: Bacteriophage]]
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[[Category: Beta-barrel]]
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[[Category: Cementing protein]]
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[[Category: Icosahedral]]
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[[Category: Membrane protein]]
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[[Category: Outer membrane protein]]
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[[Category: Sf6]]
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[[Category: Shigella]]
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[[Category: Virus assembly]]
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Current revision

The host outer membrane proteins OmpA and OmpC are packed at specific sites in the Shigella phage Sf6 virion as structural components

3nb3, resolution 19.00Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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