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3nfk

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Current revision (09:14, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3nfk' size='340' side='right'caption='[[3nfk]], [[Resolution|resolution]] 1.43&Aring;' scene=''>
<StructureSection load='3nfk' size='340' side='right'caption='[[3nfk]], [[Resolution|resolution]] 1.43&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3nfk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NFK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NFK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3nfk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rabies_lyssavirus Rabies lyssavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NFK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NFK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.43&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2vph|2vph]], [[2cs5|2cs5]], [[3nfl|3nfl]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTPN4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nfk OCA], [https://pdbe.org/3nfk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nfk RCSB], [https://www.ebi.ac.uk/pdbsum/3nfk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nfk ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nfk OCA], [https://pdbe.org/3nfk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nfk RCSB], [https://www.ebi.ac.uk/pdbsum/3nfk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nfk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PTN4_HUMAN PTN4_HUMAN]] May act at junctions between the membrane and the cytoskeleton. [[https://www.uniprot.org/uniprot/VGLG_RABVE VGLG_RABVE]] Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein G and thereby facilitate rabies virus entry into cells.
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[https://www.uniprot.org/uniprot/PTN4_HUMAN PTN4_HUMAN] May act at junctions between the membrane and the cytoskeleton.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Babault, N]]
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[[Category: Rabies lyssavirus]]
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[[Category: Buc, H]]
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[[Category: Babault N]]
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[[Category: Cockburn, J]]
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[[Category: Buc H]]
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[[Category: Cordier, F]]
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[[Category: Cockburn J]]
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[[Category: Delepierre, M]]
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[[Category: Cordier F]]
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[[Category: Haouz, A]]
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[[Category: Delepierre M]]
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[[Category: Lafage, M]]
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[[Category: Haouz A]]
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[[Category: Lafon, M]]
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[[Category: Lafage M]]
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[[Category: Rey, F A]]
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[[Category: Lafon M]]
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[[Category: Wolff, N]]
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[[Category: Rey FA]]
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[[Category: Pdz-pdz-binding site complex]]
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[[Category: Wolff N]]
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[[Category: Protein binding]]
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Current revision

Crystal structure of the PTPN4 PDZ domain complexed with the C-terminus of a rabies virus G protein

PDB ID 3nfk

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