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3nio

From Proteopedia

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Current revision (16:46, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3nio' size='340' side='right'caption='[[3nio]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3nio' size='340' side='right'caption='[[3nio]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3nio]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NIO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3nio]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NIO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3nip|3nip]], [[3niq|3niq]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gbuA, PA1421 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Guanidinobutyrase Guanidinobutyrase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.7 3.5.3.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nio OCA], [https://pdbe.org/3nio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nio RCSB], [https://www.ebi.ac.uk/pdbsum/3nio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nio ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nio OCA], [https://pdbe.org/3nio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nio RCSB], [https://www.ebi.ac.uk/pdbsum/3nio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nio ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GBUA_PSEAE GBUA_PSEAE] Catalyzes specifically the hydrolysis of 4-guanidinobutanoate to 4-aminobutanoate and urea. Has no activity against arginine, agmatine, 3-guanidinopropionate and guanidinoacetate.<ref>PMID:12029055</ref> <ref>PMID:21600989</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Guanidinobutyrase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Pseae]]
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[[Category: Pseudomonas aeruginosa PAO1]]
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[[Category: An, D]]
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[[Category: An D]]
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[[Category: Im, H]]
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[[Category: Im H]]
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[[Category: Jang, J Y]]
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[[Category: Jang JY]]
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[[Category: Kim, D J]]
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[[Category: Kim DJ]]
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[[Category: Kim, H S]]
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[[Category: Kim HS]]
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[[Category: Kim, K H]]
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[[Category: Kim KH]]
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[[Category: Lee, S J]]
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[[Category: Lee SJ]]
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[[Category: Suh, S W]]
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[[Category: Suh SW]]
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[[Category: Yoon, H J]]
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[[Category: Yoon HJ]]
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[[Category: Yoon, J Y]]
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[[Category: Yoon JY]]
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[[Category: Gbua]]
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[[Category: Hydrolase]]
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[[Category: Pa1421]]
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Current revision

Crystal structure of Pseudomonas aeruginosa guanidinobutyrase

PDB ID 3nio

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