1h3z

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{{STRUCTURE_1h3z| PDB=1h3z | SCENE= }}
{{STRUCTURE_1h3z| PDB=1h3z | SCENE= }}
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'''SOLUTION STRUCTURE OF A PWWP DOMAIN FROM SCHIZOSACCHAROMYCES POMBE'''
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===SOLUTION STRUCTURE OF A PWWP DOMAIN FROM SCHIZOSACCHAROMYCES POMBE===
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==Overview==
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The PWWP domain is a ubiquitous eukaryotic protein module characterised by a region of sequence similarity of approximately 80 amino acids containing a highly conserved PWWP motif. It is frequently found in proteins associated with chromatin. We have determined the structure of a PWWP domain from the S. pombe protein SPBC215.07c using NMR spectroscopy. The structure is composed of a five stranded beta barrel followed by two alpha helices. Comparison to the recently reported structure of a homologous domain from the mammalian DNA methyltransferase Dnmt3b reveals substantial differences both in the C-terminal helical region and in the PWWP motif.
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{{ABSTRACT_PUBMED_12842472}}
==About this Structure==
==About this Structure==
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1H3Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H3Z OCA].
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1H3Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H3Z OCA].
==Reference==
==Reference==
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[[Category: Chromatin]]
[[Category: Chromatin]]
[[Category: Pwwp]]
[[Category: Pwwp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:24:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:35:01 2008''

Revision as of 03:35, 1 July 2008

Image:1h3z.png

Template:STRUCTURE 1h3z

SOLUTION STRUCTURE OF A PWWP DOMAIN FROM SCHIZOSACCHAROMYCES POMBE

Template:ABSTRACT PUBMED 12842472

About this Structure

1H3Z is a Single protein structure of sequence from Schizosaccharomyces pombe. Full experimental information is available from OCA.

Reference

Structural variation in PWWP domains., Slater LM, Allen MD, Bycroft M, J Mol Biol. 2003 Jul 11;330(3):571-6. PMID:12842472

Page seeded by OCA on Tue Jul 1 06:35:01 2008

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