This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.

3o81

From Proteopedia

(Difference between revisions)

Jump to: navigation, search

Current revision

Beta2-microglobulin from Gallus gallus

Structural highlights

3o81 is a 2 chain structure with sequence from Gallus gallus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

B2MG_CHICK Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

Publication Abstract from PubMed

beta(2)-microglobulin (beta(2)m) is the smallest building block of molecules belonging to the immunoglobulin superfamily. By comparing thermodynamic and structural characteristics of chicken beta(2)m with those of other species, we seek to elucidate whether it is possible to pinpoint features that set the avian protein apart from other beta(2)m. The thermodynamic assays revealed that chicken beta(2)m exhibits a lower melting temperature than human beta(2)m, and the H/D exchange behavior observed by infrared spectroscopy indicates a more flexible structure of the former protein. To understand these differences at a molecular level, we determined the structure of free chicken beta(2)m by X-ray crystallography to a resolution of 2.0 A. Our comparisons indicate that certain biophysical characteristics of the chicken protein, particularly its conformational flexibility, diverge considerably from those of the other beta(2)m analyzed, although basic structural features have been retained through evolution.

Comparative biophysical characterization of chicken beta2-microglobulin.,Hee CS, Fabian H, Uchanska-Ziegler B, Ziegler A, Loll B Biophys Chem. 2012 Jun;167:26-35. doi: 10.1016/j.bpc.2012.04.001. PMID:22695053^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Hee CS, Fabian H, Uchanska-Ziegler B, Ziegler A, Loll B. Comparative biophysical characterization of chicken beta2-microglobulin. Biophys Chem. 2012 Jun;167:26-35. doi: 10.1016/j.bpc.2012.04.001. PMID:22695053 doi:http://dx.doi.org/10.1016/j.bpc.2012.04.001

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3o81"

@@ Line 3: / Line 3: @@
 <StructureSection load='3o81' size='340' side='right'caption='[[3o81]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3o81]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O81 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3o81]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O81 FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3bev|3bev]], [[3bew|3bew]], [[1bmg|1bmg]], [[1lds|1lds]], [[3gbl|3gbl]]</div></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">B2M ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o81 OCA], [https://pdbe.org/3o81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o81 RCSB], [https://www.ebi.ac.uk/pdbsum/3o81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o81 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/B2MG_CHICK B2MG_CHICK]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
+[https://www.uniprot.org/uniprot/B2MG_CHICK B2MG_CHICK] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 26: / Line 25: @@
 __TOC__
 </StructureSection>
-[[Category: Chick]]
+[[Category: Gallus gallus]]
 [[Category: Large Structures]]
-[[Category: Hee, C S]]
+[[Category: Hee CS]]
-[[Category: Loll, B]]
+[[Category: Loll B]]
-[[Category: Uchanska-Ziegler, B]]
+[[Category: Uchanska-Ziegler B]]
-[[Category: Ziegler, A]]
+[[Category: Ziegler A]]
-[[Category: Histocompatibility antigen]]
-[[Category: Immune system]]
-[[Category: Mhc class i molecule from b21 chicken]]

3o81

From Proteopedia

Current revision

Beta2-microglobulin from Gallus gallus

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox