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Transducin 3D structures

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Line 18: Line 18:
**[[7ewp]], [[7ewr]] – hTDN + RGS7 + GPR158<br />
**[[7ewp]], [[7ewr]] – hTDN + RGS7 + GPR158<br />
 +
**[[8sg8]], [[8sg9]], [[8sgc]], [[8sgl]], [[8sh9]], [[8sha]], [[8shd]], [[8she]], [[8shf]], [[8shg]], [[8shl]], [[8shn]], [[8sho]], [[8shp]], [[8shq]], [[8sht]] – hTDN + T-complex proteins + phosducin-like protein – Cryo EM<br />
**[[6n9g]] – mTDN + RGS7 - mouse<br />
**[[6n9g]] – mTDN + RGS7 - mouse<br />
**[[7shf]] – mTDN + RGS7 – Cryo EM<br />
**[[7shf]] – mTDN + RGS7 – Cryo EM<br />
Line 26: Line 27:
**[[4kfm]] – hTDN + G-protein activated inward rectifier K+ channel<br />
**[[4kfm]] – hTDN + G-protein activated inward rectifier K+ channel<br />
**[[6m8s]] – hTDN + KCTD12<br />
**[[6m8s]] – hTDN + KCTD12<br />
-
**[[7sf7]], [[7fs8]] – hTDN + adhesion GPC receptor + G protein subunit 13 – Cryo EM<br />
+
**[[8ddw]], [[8ddx]] – hTDN + TRPM3 – Cryo EM<br />
-
**[[6nbi]], [[6nbh]], [[6nbf]] – hTDN + PTH/PTHRP + long-acting parathyroid hormone + GS protein a subunit + nanobody – Cryo EM<br />
+
**[[8emw]], [[8emx]] – hTDN + phospholipase C beta-3 – Cryo EM<br />
**[[1tbg]] – bTDN <br />
**[[1tbg]] – bTDN <br />
**[[2trc]], [[1a0r]], [[1b9x]], [[1b9y]] – bTDN + phosducin<br />
**[[2trc]], [[1a0r]], [[1b9x]], [[1b9y]] – bTDN + phosducin<br />
Line 46: Line 47:
**[[6eg8]] – hTDN + GDP<br />
**[[6eg8]] – hTDN + GDP<br />
-
**[[6d9h]] – hTDN + AChR/adenosine receptor – Cryo EM<br />
 
-
**[[6g79]], [[7e2x]], [[7e32]], [[7e33]] – hTDN + serotonin receptor – Cryo EM<br />
 
-
**[[7d76]], [[7wu4]], [[7wu5]] – hTDN + adhesion GPC receptor – Cryo EM<br />
 
**[[7mts]] – hTDN + glutamate receptor – Cryo EM<br />
**[[7mts]] – hTDN + glutamate receptor – Cryo EM<br />
**[[7vh0]] – hTDN + melatonin receptor – Cryo EM<br />
**[[7vh0]] – hTDN + melatonin receptor – Cryo EM<br />
-
**[[7f1q]], [[7f1r]], [[7f1s]] – hTDN + chemokine receptor – Cryo EM<br />
 
**[[7fig]], [[7fih]], [[7fii]] – bTDN + leutinizing hormone/choriogonadotropin receptor – Cryo EM<br />
**[[7fig]], [[7fih]], [[7fii]] – bTDN + leutinizing hormone/choriogonadotropin receptor – Cryo EM<br />
**[[1got]] – bTDN + GDP<br />
**[[1got]] – bTDN + GDP<br />
-
*Transducin-α+βγ ternary complex
+
*Transducin-α+βγ complex with mu opioid receptor
-
**[[6ddf]], [[6dde]] – hTDN + mu opioid receptor + DAMGO – Cryo EM<br />
+
**[[6ddf]], [[6dde]], [[8efq]] – hTDN + mu opioid receptor + DAMGO – Cryo EM<br />
-
**[[6p9x]] – hTDN + CRFR-1 + corticliberin – Cryo EM<br />
+
**[[7u2k]] – hTDN + mu opioid receptor + ligand – Cryo EM<br />
-
**[[6osa]] – hTDN + NTR1 + JMV449 – Cryo EM<br />
+
**[[7sbf]], [[7scg]], [[7t2g]], [[7u2l]], [[8efo]] – hTDN + mu opioid receptor + scFv + ligand – Cryo EM<br />
 +
**[[7t2h]], [[8ef5]], [[8efb]], [[8efl]], [[8f7r]] – hTDN + mu opioid receptor + scFv + drug – Cryo EM<br />
 +
**[[8ef6]], [[8f7q]] – hTDN + mu opioid receptor + scFv + morphine derivative– Cryo EM<br />
 +
 
 +
*Transducin-α+βγ complex with kappa opioid receptor
 +
 
 +
**[[8dzp]], [[8dzq]], [[8f7w]] – hTDN + kappa opioid receptor + drug + scFv – Cryo EM<br />
 +
**[[8dzs]] – hTDN + kappa opioid receptor + ligand + scFv – Cryo EM<br />
 +
**[[7y1f]], [[8feg]] – hTDN + kappa opioid receptor + peptide agonist + scFv – Cryo EM<br />
 +
**[[8dzr]] – hTDN + kappa opioid receptor + scFv – Cryo EM<br />
 +
 
 +
*Transducin-α+βγ complex with serotonin (or hydroxytryptamine) receptor
 +
 
 +
**[[6g79]], [[7e2x]], [[7e32]], [[7e33]] – hTDN + serotonin receptor – Cryo EM<br />
**[[7e2z]] – hTDN + serotonin receptor + drug – Cryo EM<br />
**[[7e2z]] – hTDN + serotonin receptor + drug – Cryo EM<br />
-
**[[7e2y]] – hTDN + serotonin receptor + serotonin – Cryo EM<br />
+
**[[7e2y]] , [[7xt9]] – hTDN + serotonin receptor + serotonin – Cryo EM<br />
-
**[[7l0p]], [[7l0q]], [[7l0r]], [[7l0s]] – hTDN + neurotensin receptor + neurotensin – Cryo EM<br />
+
**[[6wha]], [[7exd]], [[7um5]], [[7x5h]], [[7ys6]], [[8dpg]]] – hTDN + serotonin receptor + scFv – Cryo EM<br />
-
**[[7lci]] – hTDN + glucagon-like peptide receptor + inhibitor – Cryo EM<br />
+
**[[8jlz]] – hTDN + serotonin receptor + nanobody – Cryo EM<br />
-
**[[7f1r]], [[7f1s]] – hTDN + chemokine receptor – Cryo EM<br />
+
**[[7srr]] – hTDN + serotonin receptor + LSD + scFv – Cryo EM<br />
 +
**[[7um6]], [[7um7]], [[8dpf]], [[8dph]], [[8dpi]], [[8w8b]] – hTDN + serotonin receptor + drug + scFv – Cryo EM<br />
 +
**[[7ran]] – hTDN + serotonin receptor + agonist + scFv – Cryo EM<br />
 +
**[[7xta]] – hTDN + serotonin receptor + scFv + serotonin – Cryo EM<br />
 +
**[[7xt8]], [[7xtb]], [[7xtc]] – hTDN + serotonin receptor + nanobody + serotonin – Cryo EM<br />
 +
 
 +
*Transducin-α+βγ complex with dopamine receptor
 +
 
 +
**[[7f1z]] – hTDN + dopamine receptor + dopamine + GDP – Cryo EM<br />
 +
**[[7f24]] – hTDN + dopamine receptor + dopamine + GTP – Cryo EM<br />
 +
**[[6vms]], [[7cmu]], [[7cmv]] – r/hTDN + dopamine receptor + scFv <br />
 +
**[[7ljd]] – hTDN + dopamine receptor + nanobody – Cryo EM<br />
 +
**[[7jvr]] – hTDN + dopamine receptor + ligand + scFv – Cryo EM<br />
 +
**[[7x2c]], [[8irs]], [[8irt]] – hTDN + dopamine receptor + drug + scFv – Cryo EM<br />
 +
**[[7cky]], [[7crh]], [[7jv5]], [[7jvp]], [[7jvq]] – hTDN + dopamine receptor + ligand + nanobody – Cryo EM<br />
 +
**[[7x2f]] – hTDN + dopamine receptor + agonist + nanobody – Cryo EM<br />
 +
**[[7jvq]] – hTDN + dopamine receptor + dopamine + nanobody – Cryo EM<br />
 +
**[[7x2d]] – hTDN + dopamine receptor + drug + nanobody – Cryo EM<br />
 +
**[[7f1o]], [[7f23]] – hTDN + dopamine receptor + dopamine + GTP + nanobody – Cryo EM<br />
 +
**[[7ckw]], [[7ckx]], [[7ckz]], [[7ljc]], [[7joz]] – hTDN + dopamine receptor + scFv + nanobody – Cryo EM<br />
 +
 
 +
*Transducin-α+βγ complex with cholecystokinin receptor
 +
 
**[[7mby]] – hTDN + cholecystokinin receptor + cholecystokinin – Cryo EM<br />
**[[7mby]] – hTDN + cholecystokinin receptor + cholecystokinin – Cryo EM<br />
-
**[[7f6i]] – hTDN + bradykinin receptor + kallidin + cholesterol – Cryo EM<br />
 
-
**[[7f6h]] – hTDN + bradykinin receptor + bradykinin + cholesterol – Cryo EM<br />
 
-
**[[7eib]] – hTDN + bradykinin receptor + polypeptide – Cryo EM<br />
 
**[[7f8w]] – hTDN + cholecystokinin receptor + gastrin – Cryo EM<br />
**[[7f8w]] – hTDN + cholecystokinin receptor + gastrin – Cryo EM<br />
-
**[[7t6u]], [[7t6v]], [[7t6t]], [[7wvv]], [[7wvw]] – hTDN + formyl peptide receptor + peptide agonist – Cryo EM<br />
+
**[[7ezh]] – hTDN + cholecystokinin receptor + scFv – Cryo EM<br />
 +
**[[7ezk]], [[7ezm]], [[8ia7]] – hTDN + cholecystokinin receptor + cholecystokinin peptide + scFv – Cryo EM<br />
 +
**[[7f8v]], [[7f8w]] – hTDN + cholecystokinin receptor + gastrin peptide + scFv – Cryo EM<br />
 +
**[[7mbx]] – hTDN + cholecystokinin receptor + cholecystokinin + nanobody – Cryo EM<br />
 +
 
 +
 
 +
*Transducin-α+βγ complex with glucagon receptor
 +
 
 +
**[[7c2e]] – hTDN + glucagon receptor + nanobody – Cryo EM<br />
 +
**[[6whc]] – hTDN + glucagon receptor + dual-agonist peptide + nanobody – Cryo EM<br />
 +
**[[6lmk]], [[6lml]], [[6x1a]], [[6x19]], [[6x18]], [[6wpw]], [[5vai]], [[6vcb]], [[8fu6]], [[8jiq]]– hTDN + glucagon receptor + glucagon peptide + nanobody – Cryo EM<br />
 +
**[[8jit]], [[8jiu]]– hTDN + glucagon receptor + peptide agonist + nanobody – Cryo EM<br />
 +
 
 +
*Transducin-α+βγ complex with glucagon-like peptide receptor
 +
 
 +
**[[7lci]] – hTDN + glucagon-like peptide receptor + inhibitor – Cryo EM<br />
 +
**[[7c2e]], [[7duq]], [[7dur]], [[7e14]], [[7evm]], [[7s3i]] – hTDN + glucagon-like peptide receptor + nanobody – Cryo EM<br />
 +
**[[6xox]], [[7rg9]] – hTDN + glucagon-like peptide receptor + scFv + nanobody – Cryo EM<br />
 +
**[[7rgp]] – hTDN + glucagon-like peptide receptor + scFv + nanobody + polypeptide – Cryo EM<br />
 +
**[[7ki0]], [[7ki1]], [[7d68]], [[7rtb]], [[7s1m]] – hTDN + glucagon-like peptide receptor + nanobody + glucagon derivative – Cryo EM<br />
 +
**[[7lll]] – hTDN + glucagon-like peptide receptor + nanobody + exendin – Cryo EM<br />
 +
**[[7fim]], [[7lly]], [[7v35]], [[7vbh]], [[7vbi]] – hTDN + glucagon-like peptide receptor + nanobody + polypeptide – Cryo EM<br />
 +
 
 +
*Transducin-α+βγ complex with formyl peptide receptor
 +
 
 +
**[[7t6u]], [[7t6v]], [[7t6t]], [[7vfx]], [[7wvv]], [[7wvw]] – hTDN + formyl peptide receptor + peptide agonist – Cryo EM<br />
**[[7wvy]] – hTDN + formyl peptide receptor + amyloid-beta A4 – Cryo EM<br />
**[[7wvy]] – hTDN + formyl peptide receptor + amyloid-beta A4 – Cryo EM<br />
**[[7wvx]] – hTDN + formyl peptide receptor + humanin – Cryo EM<br />
**[[7wvx]] – hTDN + formyl peptide receptor + humanin – Cryo EM<br />
 +
**[[7euo]], [[7wvu]] – hTDN + formyl peptide receptor + scFv + formyl peptide – Cryo EM<br />
 +
**[[6omm]], [[7t6s]] – hTDN + formyl peptide receptor + scFv + agonist – Cryo EM<br />
 +
 +
*Transducin-α+βγ complex with adrenergic receptor
 +
 +
**[[7s0f]], [[7s0g]] – bTDN + adrenergic receptor + drug – Cryo EM<br />
 +
**[[6k41]], [[6k42]], [[7w7e]] – hTDN + adrenergic receptor + scFv – Cryo EM<br />
 +
**[[6ni3]] – hTDN + endolysin/adrenergic receptor + nanobody – Cryo EM<br />
 +
**[[7dh5]] – hTDN + adrenergic receptor + nanobody – Cryo EM<br />
 +
**[[7bz2]] – h/bTDN + adrenergic receptor + nanobody – Cryo EM<br />
 +
**[[7jjo]] – bTDN + adrenergic receptor + nanobody – Cryo EM<br />
 +
**[[7ej0]], [[7ej8]], [[7eja]], [[7ejk]], [[8dcr]] – hTDN + adrenergic receptor + scFv + drug – Cryo EM<br />
 +
**[[7w6p]], [[8thk]] – hTDN + adrenergic receptor + scFv + agonist – Cryo EM<br />
 +
**[[8thl]] – hTDN + adrenergic receptor + scFv + adrenaline + epinephrin – Cryo EM<br />
 +
**[[7bz2]], [[7dhi]], [[7dhr]] – hTDN + adrenergic receptor + nanobody + agonist – Cryo EM<br />
 +
**[[7xjh]], [[7xji]], [[8dcs]] – hTDN + adrenergic receptor + nanobody + drug – Cryo EM<br />
 +
 +
*Transducin-α+βγ complex with somatostatin receptor
 +
 +
**[[7xmr]] – hTDN + somatostatin receptor + somatostatin – Cryo EM<br />
 +
**[[7t11]], [[7xau]], [[7xav]], [[7y24]], [[7yac]] – hTDN + somatostatin receptor + scFv + drug – Cryo EM<br />
 +
**[[7t10]], [[7wj5]], [[7xat]], [[7xms]], [[7y26]], [[7y27]] – hTDN + somatostatin receptor + scFv + somatostatin peptide – Cryo EM<br />
 +
**[[7xmt]] – hTDN + somatostatin receptor + scFv + ligand – Cryo EM<br />
 +
**[[7wig]] – hTDN + somatostatin receptor + scFv + agonist – Cryo EM<br />
 +
**[[7wic]] – hTDN + somatostatin receptor + scFv + somastatin – Cryo EM<br />
 +
**[[7yae]] – hTDN + somatostatin receptor + scFv + peptide – Cryo EM<br />
 +
 +
*Transducin-α+βγ complex with melanocortin receptor
 +
 +
**[[8gy7]] – hTDN + melanocortin receptor + melanocortin + melanocortin receptor accessory protein – Cryo EM<br />
 +
**[[8inr]] – hTDN + melanocortin receptor + melanocyte-stimulating hormone – Cryo EM<br />
 +
**[[7f4d]], [[7f4f]], [[7f4h]], [[7f4i]], [[7f58]] – hTDN + melanocortin receptor + nanobody – Cryo EM<br />
 +
**[[7f53]], [[7f54]], [[7f55]], [[7piu]], [[7piv]] – hTDN + melanocortin receptor + nanobody + peptide agonist – Cryo EM<br />
 +
**[[8ioc]] – hTDN + melanocortin receptor + nanobody + melanocyte-stimulating hormone – Cryo EM<br />
 +
**[[8iod]] – hTDN + melanocortin receptor + nanobody + agonist – Cryo EM<br />
 +
 +
*Transducin-α+βγ complex with TRACE amine receptor
 +
 +
**[[8jlo]] – hTDN + TRACE amine receptor + drug – Cryo EM<br />
 +
**[[8wc4]], [[8wca]] – hTDN + TRACE amine receptor + scFv – Cryo EM<br />
 +
**[[8w88]] – hTDN + TRACE amine receptor + nanobody – Cryo EM<br />
 +
**[[8jlp]], [[8jlq]] – hTDN + TRACE amine receptor + scFv + drug – Cryo EM<br />
 +
**[[8jlj]], [[8jlk]], [[8jln]], [[8jlr]], [[8jso]], [[8wc5]], [[8wc6]], [[8wc7]], [[8wc8]], [[8wc9]], [[8wcb]] – hTDN + TRACE amine receptor + scFv + agonist – Cryo EM<br />
 +
**[[8w87]], [[8w89]], [[8w8a]], [[8wc3]] – hTDN + TRACE amine receptor + nanobody + drug – Cryo EM<br />
 +
 +
*Transducin-α+βγ complex with acetylcholine receptor
 +
 +
**[[6oik]], [[6oij]], [[7t90]], [[7trs]], [[7v68]], [[7v69]], ]]8e9w]], [[8e9x]], [[8e9y]] – hTDN + AChR + scFv – Cryo EM<br />
 +
**[[7tbx]] – hTDN + AChR + antibody – Cryo EM<br />
 +
**[[7trk]], [[8e9z]], [[8fx5]] – hTDN + AChR + agonist + scFv – Cryo EM<br />
 +
**[[7t94]] – hTDN + AChR + ACh + scFv – Cryo EM<br />
 +
**[[7v6a]] – hTDN + AChR + scFv + piperidine derivative – Cryo EM<br />
 +
**[[7t96]] – hTDN + AChR + ACh + scFv + modulator – Cryo EM<br />
 +
**[[7trp]], [[7trq]] – hTDN + AChR + agonist + modulator + scFv – Cryo EM<br />
 +
**[[6d9h]] – hTDN + AChR/adenosine receptor – Cryo EM<br />
 +
 +
*Transducin-α+βγ complex with adhesion GPC receptor
 +
 +
**[[7sf7]], [[7fs8]] – hTDN + adhesion GPC receptor + G protein subunit 13 – Cryo EM<br />
 +
**[[7d76]], [[7wu4]], [[7wu5]] – hTDN + adhesion GPC receptor – Cryo EM<br />
 +
**[[7d77]], [[7eq1]], [[7tuz]], [[7x10]], [[7x2v]] – hTDN + adhesion GPC receptor + scFv – Cryo EM<br />
 +
**[[7ept]], [[7wuq]], [[7wxu]], [[7wxw]], [[7xkd]], [[7xke]], [[7xv3]], [[7y3g]], [[7ydm]], [[7ydp]], [[8g2y]], [[8hix]], [[8hj0]], [[8hj1]], [[8hj2]], [[8hmp]], [[8hmv]], [[8kgk]] – hTDN + adhesion GPC receptor + nanobody – Cryo EM<br />
 +
**[[7rkx]], [[7rky]] – hTDN + GPC receptor + scFv + GDP – Cryo EM<br />
 +
**[[7rkf]], [[7rkm]], [[7rkn]] – hTDN + GPC receptor + scFv + fractalkine – Cryo EM<br />
 +
**[[7ejx]], [[7vug]] – hTDN + GPC receptor + scFv + ligand – Cryo EM<br />
 +
**[[7vuh]], [[7vui]], [[7vuj]] – hTDN + GPC receptor + nanobody + ligand – Cryo EM<br />
 +
**[[7wu2]], [[7wu3]], [[7wui]], [[7wuj]] – hTDN + adhesion GPC receptor + scFv + nanobody – Cryo EM<br />
 +
 +
*Transducin-α+βγ complex with chemokine receptor
 +
 +
 +
**[[6wwz]], [[7vl8]], [[7x9y]] – hTDN + chemokine receptor + scFv – Cryo EM<br />
 +
**[[7o7f]] – hTDN + chemokine receptor + antibody – Cryo EM<br />
 +
**[[6lfm]], [[6lfo]], [[8ic0]] – hTDN + chemokine receptor + IL8 peptide + scFv – Cryo EM<br />
 +
**[[7vl9]], [[7vla]] – hTDN + chemokine receptor + scFv + CCL15 – Cryo EM<br />
 +
**[[7xa3]] – hTDN + chemokine receptor + scFv + CCL2 – Cryo EM<br />
 +
**[[8hnk]], [[8k2x]] – hTDN + chemokine receptor + scFv + c-x-c motif chemokine – Cryo EM<br />
 +
**[[8hnl]], [[8hnm]] – hTDN + chemokine receptor + scFv + activator – Cryo EM<br />
 +
**[[7f1q]], [[7f1r]], [[7f1s]] – hTDN + chemokine receptor – Cryo EM<br />
 +
**[[7xbw]], [[7xbx]] – hTDN + chemokine receptor + cholesterol – Cryo EM<br />
 +
 +
*Transducin-α+βγ complex with C3A anaphylatoxin chemotactic receptor
 +
 +
**[[8i95]], [[8i9a]], [[8j6d]] – hTDN + C3A anaphylatoxin chemotactic receptor + EP ligand + scFv – Cryo EM<br />
 +
**[[8ia8]] – hTDN + C3A anaphylatoxin chemotactic receptor + peptide + scFv – Cryo EM<br />
 +
**[[8hk3]], [[8i97]], [[8i9s]] – hTDN + C3A anaphylatoxin chemotactic receptor + scFv – Cryo EM<br />
 +
**[[8hk2]], [[8i9l]] – hTDN + C3A anaphylatoxin chemotactic receptor + C3A anaphylatoxin peptide + scFv – Cryo EM<br />
 +
**[[8i95]], [[8i9a]], [[8j6d]] – hTDN + C3A anaphylatoxin chemotactic receptor + EP ligand + scFv – Cryo EM<br />
 +
**[[8ia8]] – hTDN + C3A anaphylatoxin chemotactic receptor + peptide + scFv – Cryo EM<br />
 +
**[[8hk3]], [[8i97]], [[8i9s]] – hTDN + C3A anaphylatoxin chemotactic receptor + scFv – Cryo EM<br />
 +
**[[8hk2]], [[8i9l]] – hTDN + C3A anaphylatoxin chemotactic receptor + C3A anaphylatoxin peptide + scFv – Cryo EM<br />
 +
 +
*Transducin-α+βγ complex with C5A anaphylatoxin chemotactic receptor
 +
 +
**[[7y64]], [[7y65]], [[8hqc]], [[8jzz]], [[8ia2]] – hTDN + C5A anaphylatoxin chemotactic receptor + C5A anaphylatoxin + scFv – Cryo EM<br />
 +
**[[7y66]] – hTDN + C5A anaphylatoxin chemotactic receptor + BM213 peptide + scFv – Cryo EM<br />
 +
**[[7y67]] – hTDN + C5A anaphylatoxin chemotactic receptor + C089 peptide + scFv – Cryo EM<br />
 +
 +
*Transducin-α+βγ complex with lysophatidic receptor
 +
 +
**[[7td0]], [[7td1]], [[7td2]] – bTDN + lysophosphatidic receptor + lysophosphatidic acid – Cryo EM<br />
 +
**[[7yu3]], [[7yu7]] – h/r/bTDN + lysophosphatidic receptor + scFv – Cryo EM<br />
 +
**[[7yu5]] – h/r/bTDN + lysophosphatidic receptor + scFv + agonist – Cryo EM<br />
 +
**[[7yu6]], [[7yu8]] – hTDN + lysophosphatidic receptor + scFv + agonist – Cryo EM<br />
 +
 +
*Transducin-α+βγ complex with adenosine A2A receptor
 +
**[[7ld4]] – hTDN + adenosine A2A receptor + adenosine – Cryo EM<br />
**[[7ld4]] – hTDN + adenosine A2A receptor + adenosine – Cryo EM<br />
-
**[[7ld3]] – hTDN + adenosine A2A receptor + adenosine + agonist – Cryo EM<br />
+
**[[7xy6]] – hTDN + adenosine A2A receptor + agonist – Cryo EM<br />
 +
**[[7ld3]], [[7xy7]] – hTDN + adenosine A2A receptor + adenosine + agonist – Cryo EM<br />
 +
**[[6gdg]] – hTDN + adenosine A2A receptor + nanobody – Cryo EM<br />
 +
 
 +
*Transducin-α+βγ complex with G protein-coupled (GPR) receptor
 +
 
 +
**[[7wy0]], [[7wy5]], [[7wyb]], [[7wz4]], [[7wz7]], [[7xkf]], [[7ydh]], [[7ydj]], [[7yp7]], [[8hmv]], [[8hs3]], [[8hvi]], [[8k4n]], [[8sai]], [[8tb0]] – hTDN + G-protein coupled receptor + scFv – Cryo EM<br />
 +
**[[8hsc]] – hTDN + GPR20 + scFv + antibody – Cryo EM<br />
 +
**[[7y89]] – hTDN + GPR17 – Cryo EM<br />
 +
**[[7sf8]] – hTDN + GPR56 – Cryo EM<br />
 +
**[[6li3]] – hTDN + GPR52 + nanobody – Cryo EM<br />
 +
 
 +
 
 +
*Transducin-α+βγ complex with MAS-related receptor
 +
 
 +
**[[7s8n]], [[7s8o]], [[7s8p]] – hTDN + MAS-related receptor + scFv + ligand – Cryo EM<br />
 +
**[[8dwc]] – hTDN + MAS-related receptor + scFv + peptide agonist – Cryo EM<br />
 +
**[[8dwh]] – hTDN + MAS-related receptor + scFv + ligand – Cryo EM<br />
 +
**[[7y12]] – hTDN + MAS-related receptor + scFv + Ala – Cryo EM<br />
 +
**[[7vdh]], [[7vdl]], [[7vdm]], [[7vuy]], [[7vuz]], [[7vv3]], [[7vv5]] – hTDN + MAS-related receptor + scFv + cholesterol + ligand – Cryo EM<br />
 +
**[[7s8l]], [[7s8m]] – hTDN + MAS-related receptor + scFv + cortistatin – Cryo EM<br />
 +
**[[8hj5]] – hTDN + MAS-related receptor + nanobody + agonist – Cryo EM<br />
 +
**[[8dwg]] – hTDN + MAS-related receptor + proenkephalin + scFv – Cryo EM<br />
 +
 
 +
*Transducin-α+βγ complex with sphingosine receptor
 +
 
**[[7td3]] – hTDN + sphingosine receptor + sphingosine – Cryo EM<br />
**[[7td3]] – hTDN + sphingosine receptor + sphingosine – Cryo EM<br />
**[[7td4]] – bTDN + sphingosine receptor + drug – Cryo EM<br />
**[[7td4]] – bTDN + sphingosine receptor + drug – Cryo EM<br />
 +
**[[7t6b]], [[7wf7]] – hTDN + sphingosine receptor + scFv + sphingosine – Cryo EM<br />
 +
**[[7eo2]], [[7eo4]] – hTDN + sphingosine receptor + scFv + agonist – Cryo EM<br />
 +
**[[8g94]] – hTDN + sphingosine receptor + scFv + CD69 – Cryo EM<br />
 +
 +
*Transducin-α+βγ complex with bradykinin receptor
 +
 +
**[[7f6i]] – hTDN + bradykinin receptor + kallidin + cholesterol – Cryo EM<br />
 +
**[[7f6h]] – hTDN + bradykinin receptor + bradykinin + cholesterol – Cryo EM<br />
 +
**[[7eib]] – hTDN + bradykinin receptor + polypeptide – Cryo EM<br />
 +
**[[7f2o]] – hTDN + bradykinin receptor + scFv + polypeptide – Cryo EM<br />
 +
 +
*Transducin-α+βγ complex with galanin receptor
 +
 +
**[[7xjl]] – hTDN + galanin receptor + agonist peptide + scFv – Cryo EM<br />
 +
**[[7xjj]] – hTDN + galanin receptor + galanin peptide + scFv – Cryo EM<br />
 +
**[[7xbd]], [[7xjk]] – hTDN + galanin receptor + scFv + galanin peptide – Cryo EM<br />
 +
**[[7wq3]], [[7wq4]] – hTDN + galanin receptor + nanobody + galanin – Cryo EM<br />
 +
 +
*Transducin-α+βγ complex with PTH/PTHRP receptor
 +
 +
**[[7vvj]], [[7vvk]], [[7vvl]], [[7vvm]], [[7vvn]], [[7vvo]], [[8flq]], [[8flu]], [[8ha0]], [[8haf]] – hTDN + PTH/PTHRP receptor + parathyroid hormone + nanobody – Cryo EM<br />
 +
**[[8flr]], [[8flt]] – hTDN + PTH/PTHRP receptor + PTHRP + nanobody – Cryo EM<br />
 +
**[[8gw8]] – hTDN + PTH/PTHRP receptor + agonist + nanobody – Cryo EM<br />
 +
**[[8fls]] – hTDN + PTH/PTHRP receptor + peptide agonist + nanobody – Cryo EM<br />
 +
**[[7y35]], [[7y36]] – hTDN + PTH/PTHRP receptor + drug + nanobody – Cryo EM<br />
 +
**[[6nbi]], [[6nbh]], [[6nbf]] – hTDN + PTH/PTHRP receptor+ long-acting parathyroid hormone + GS protein a subunit + nanobody – Cryo EM<br />
 +
 +
*Transducin-α+βγ complex with calcitonin receptor
 +
 +
**[[5uz7]] – hTDN + calcitonin receptor + nanobody – Cryo EM<br />
 +
**[[8f0j]], [[8f0k]] – hTDN + calcitonin receptor + pramlintide analog peptide + nanobody – Cryo EM<br />
 +
**[[6niy]], [[6e3y]], [[7tyi]], [[7tyn]], [[7tyo]] – hTDN + calcitonin receptor + calcitonin + nanobody – Cryo EM<br />
 +
**[[7tyw]] – hTDN + calcitonin receptor + calcitonin + receptor activity-modifying protein + nanobody – Cryo EM<br />
 +
**[[7tyl]] – hTDN + calcitonin receptor + nanobody + amylin peptide – Cryo EM<br />
 +
**[[7tyf]], [[7tyh]], [[7tyx]], [[7tyy]], [[7tzf]] – hTDN + calcitonin receptor + nanobody + amylin peptide + receptor activity-modifying protein - Cryo EM<br />
 +
**[[8f2a]], [[8f2b]] – hTDN + calcitonin receptor + pramlintide analog peptide + receptor activity-modifying protein + nanobody – Cryo EM<br />
 +
 +
*Transducin-α+βγ complex with relaxin (RLN) receptor
 +
 +
**[[7tmw]] – hTDN + RLN1 receptor + nanobody – Cryo EM<br />
 +
**[[7yj4]] – hTDN + RLN3 receptor + INSL5 + scFv – Cryo EM<br />
 +
**[[7yk6]], [[7yk7]] – hTDN + RLN3 receptor + scFv – Cryo EM<br />
 +
 +
*Transducin-α+βγ complex with histamin receptor
 +
 +
**[[7dfl]] – hTDN + histamin receptor + scFv + histamin – Cryo EM<br />
 +
**[[8hn8]], [[8hoc]] – hTDN + histamin receptor + scFv + histamin – Cryo EM<br />
 +
**[[7yfd]] – hTDN + histamin receptor + nanobody + agonist – Cryo EM<br />
 +
**[[7yfc]] – hTDN + histamin receptor + scFv + nanobody + histamin – Cryo EM<br />
 +
 +
*Transducin-α+βγ complex with thyrotropin receptor
 +
 +
**[[7x1u]] – hTDN + thyrotropin receptor + peptide agonist + scFv – Cryo EM<br />
 +
**[[7xw9]] – hTDN + thyrotropin receptor + glycoprotein hormone peptide + scFv – Cryo EM<br />
 +
**[[7xw5]] – hTDN + thyrotropin receptor + glycoprotein hormone + nanobody – Cryo EM<br />
 +
**[[7utz]] – hTDN + thyrotropin receptor + thyrotropin + glycoprotein hormone + nanobody – Cryo EM<br />
 +
**[[7t9i]] – hTDN + thyrotropin receptor + nanobody + thyrotropin + gl;ycoprotein hormone – Cryo EM<br />
 +
**[[7t9n]], [[7xw6]] – hTDN + thyrotropin receptor + nanobody + antibody – Cryo EM<br />
 +
 +
*Transducin-α+βγ ternary complex
 +
 +
**[[8f7s]] – hTDN + delta opioid receptor + deltophin peptide – Cryo EM<br />
 +
**[[6p9x]] – hTDN + CRFR-1 + corticliberin – Cryo EM<br />
 +
**[[6osa]] – hTDN + NTR1 + JMV449 – Cryo EM<br />
 +
**[[7l0p]], [[7l0q]], [[7l0r]], [[7l0s]] – hTDN + neurotensin receptor + neurotensin – Cryo EM<br />
 +
**[[7xk8]] – hTDN + neuromedin receptor + neuromedin – Cryo EM<br />
 +
**[[8uqo]] – hTDN + PLC-beta-3 + GDP – Cryo EM<br />
 +
**[[7x9c]] – hTDN + neuropeptide receptor + pancreatic hormone peptide – Cryo EM<br />
 +
**[[7f6g]] – hTDN + angiotensin receptor + peptide agonist – Cryo EM<br />
**[[6oy9]] – bTDN + rhodopsin + retinal – Cryo EM<br />
**[[6oy9]] – bTDN + rhodopsin + retinal – Cryo EM<br />
-
**[[7s0f]], [[7s0g]] – bTDN + adrenergic receptor + drug – Cryo EM<br />
+
 
-
**[[7td0]], [[7td1]], [[7td2]] – bTDN + lysophosphatidic receptor + lysophosphatidic acid – Cryo EM<br />
+
**[[1gg2]] – rTDN (mutant) + bbc + GDP - rat<br />
**[[1gg2]] – rTDN (mutant) + bbc + GDP - rat<br />
**[[1gp2]], [[5kdo]] – rTDN + bbc + GDP <br />
**[[1gp2]], [[5kdo]] – rTDN + bbc + GDP <br />
Line 87: Line 341:
*Transducin-α+βγ ternary complex with scFv
*Transducin-α+βγ ternary complex with scFv
-
**[[6pt0]], [[6n4b]], [[6kpg]], [[6kpf]] – hTDN + cannaboid receptor + scFv – Cryo EM<br />
+
**[[6pt0]], [[6n4b]], [[6kpg]], [[6kpf]], [[7wv9]], [[8gur]], [[8gus]] – hTDN + cannabinoid receptor + scFv – Cryo EM<br />
-
**[[6oik]], [[6oij]] – hTDN + AChR + scFv – Cryo EM<br />
+
**[[6crk]] – hTDN + scFv <br />
**[[6crk]] – hTDN + scFv <br />
-
**[[6vms]], [[7cmu]], [[7cmv]] – r/hTDN + dopamine receptor + scFv <br />
 
-
**[[7d77]], [[7tuz]] – hTDN + adhesion GPC receptor + scFv – Cryo EM<br />
 
-
**[[7ezh]] – hTDN + cholecystokinin receptor + scFv – Cryo EM<br />
 
-
**[[7exd]] – hTDN + serotonin receptor + scFv – Cryo EM<br />
 
-
**[[7evy]], [[7evz]], [[7ew0]], [[7ew1]], [[7ew2]], [[7ew3]], [[7ew4]], [[7ew7]] – hTDN + S1P receptor + scFv – Cryo EM<br />
 
**[[7vkt]] – hTDN + leukotriene B4 receptor + scFv – Cryo EM<br />
**[[7vkt]] – hTDN + leukotriene B4 receptor + scFv – Cryo EM<br />
-
**[[7wvu]] – hTDN + formyl peptide receptor + scFv + formyl peptide – Cryo EM<br />
 
-
**[[6omm]], [[7t6s]] – hTDN + formyl peptide receptor + scFv + agonist – Cryo EM<br />
 
-
**[[6k41]], [[6k42]] – hTDN + adrenergic receptor + scFv – Cryo EM<br />
 
-
**[[6wwz]], [[7vl8]] – hTDN + chemokine receptor + scFv – Cryo EM<br />
 
**[[7eb2]] – hTDN + GABA receptor + scFv – Cryo EM<br />
**[[7eb2]] – hTDN + GABA receptor + scFv – Cryo EM<br />
**[[7db6]] – hTDN + melatonin receptor + scFv – Cryo EM<br />
**[[7db6]] – hTDN + melatonin receptor + scFv – Cryo EM<br />
**[[7jhj]] – hTDN + BILF1 + scFv – Cryo EM<br />
**[[7jhj]] – hTDN + BILF1 + scFv – Cryo EM<br />
-
**[[7l1u]] – hTDN + orexin receptor + scFv – Cryo EM<br />
+
**[[7l1u]], [[7sr8]] – hTDN + orexin receptor + scFv – Cryo EM<br />
**[[7e9h]] – hTDN + glutamate receptor + scFv – Cryo EM<br />
**[[7e9h]] – hTDN + glutamate receptor + scFv – Cryo EM<br />
-
**[[7v68]], [[7v69]] – hTDN + muscarinic acetylcholine receptor + scFv – Cryo EM<br />
+
**[[8iys]] – hTDN + FFA-R4 + scFv – Cryo EM<br />
-
**[[6wha]] – hTDN + hydroxytryptamine receptor + scFv – Cryo EM<br />
+
**[[7y15]] – hTDN + MRGD + scFv – Cryo EM<br />
 +
**[[8eit]], [[8g59]] – hTDN + free fatty acid receptor + scFv – Cryo EM<br />
 +
**[[7xk2]], [[8jim]], [[8jz7]] – hTDN + hydroxycarboxylic acid receptor + scFv – Cryo EM<br />
 +
**[[7wu9]] – hTDN + prostaglandin receptor + scFv – Cryo EM<br />
**[[6xbk]], [[6xbj]], [[6xbl]], [[6xbm]] – hTDN + smoothened homolog + scFv – Cryo EM<br />
**[[6xbk]], [[6xbj]], [[6xbl]], [[6xbm]] – hTDN + smoothened homolog + scFv – Cryo EM<br />
**[[3sn6]] – TDN ba (mutant) + rb (mutant) + bc + endolysine + scFv<br />
**[[3sn6]] – TDN ba (mutant) + rb (mutant) + bc + endolysine + scFv<br />
Line 112: Line 359:
*Transducin-α+βγ ternary complex with nanobody
*Transducin-α+βγ ternary complex with nanobody
-
**[[7ept]], [[7wuq]] – hTDN + adhesion GPC receptor + nanobody – Cryo EM<br />
 
-
**[[6ni3]] – hTDN + endolysin/adrenergic receptor + nanobody – Cryo EM<br />
 
**[[7f16]] – hTDN + PTH2 receptor + nanobody – Cryo EM<br />
**[[7f16]] – hTDN + PTH2 receptor + nanobody – Cryo EM<br />
-
**[[7c2e]], [[7duq]], [[7dur]], [[7e14]], [[7evm]], [[7s3i]] – hTDN + glucagon-like peptide receptor + nanobody – Cryo EM<br />
 
**[[7evw]] – hTDN + frizzled-7 + minGas + nanobody – Cryo EM<br />
**[[7evw]] – hTDN + frizzled-7 + minGas + nanobody – Cryo EM<br />
-
**[[7dh5]] – hTDN + adrenergic receptor + nanobody – Cryo EM<br />
+
**[[7cx2]], [[7cx3]], [[7cx4]], [[7d7m]] – hTDN + prostaglandin receptor + nanobody – Cryo EM<br />
-
**[[7cx2]], [[7cx3]], [[7cx4]] – hTDN + prostaglandin receptor + nanobody – Cryo EM<br />
+
-
**[[7f4d]], [[7f4f]], [[7f4h]], [[7f4i]], [[7f58]] – hTDN + melanocortin receptor + nanobody – Cryo EM<br />
+
-
**[[7ljd]] – hTDN + dopamine receptor + nanobody – Cryo EM<br />
+
**[[7v9l]] – hTDN + GHRH receptor + nanobody – Cryo EM<br />
**[[7v9l]] – hTDN + GHRH receptor + nanobody – Cryo EM<br />
**[[6p9y]], [[6lpb]], [[6m1i]] – hTDN + PACAP + nanobody – Cryo EM<br />
**[[6p9y]], [[6lpb]], [[6m1i]] – hTDN + PACAP + nanobody – Cryo EM<br />
-
**[[6li3]] – hTDN + GPR52 + nanobody – Cryo EM<br />
 
-
**[[6gdg]] – hTDN + adenosine A2A receptor + nanobody – Cryo EM<br />
 
**[[7bw0]], [[7cfm]], [[7cfn]] – hTDN + bile acid receptor + nanobody – Cryo EM<br />
**[[7bw0]], [[7cfm]], [[7cfn]] – hTDN + bile acid receptor + nanobody – Cryo EM<br />
-
**[[5uz7]] – hTDN + calcitonin receptor + nanobody – Cryo EM<br />
+
**[[8itl]], [[8itm]] – hTDN + GIP receptor + nanobody – Cryo EM<br />
-
**[[7c2e]] – hTDN + glucagon receptor + nanobody – Cryo EM<br />
+
**[[7xp4]], [[7xp5]], [[7xp6]] – hTDN + taste receptor 2 + nanobody – Cryo EM<br />
-
**[[7d7m]] – hTDN + prostaglandin receptor + nanobody – Cryo EM<br />
+
**[[7wcm]], [[7wcn]], [[7xz5]] – hTDN + insulinotropic receptor + nanobody – Cryo EM<br />, [[7xz6]]
-
**[[7bz2]] – h/bTDN + adrenergic receptor + nanobody – Cryo EM<br />
+
**[[7xov]] – hTDN + CCK-A receptor + nanobody – Cryo EM<br />
-
**[[7jjo]] – bTDN + adrenergic receptor + nanobody – Cryo EM<br />
+
**[[8f76]], [[8hti]] – hTDN + olfactory receptor + nanobody – Cryo EM<br />
*Transducin-α+βγ ternary complex with antibody
*Transducin-α+βγ ternary complex with antibody
-
**[[7o7f]] – hTDN + chemokine receptor + antibody – Cryo EM<br />
 
**[[6ot0]] – hTDN + antibody + smoothened homolog – Cryo EM<br />
**[[6ot0]] – hTDN + antibody + smoothened homolog – Cryo EM<br />
**[[6cmo]] – hTDN + antibody + rhodopsin/cytochrome b562 – Cryo EM<br />
**[[6cmo]] – hTDN + antibody + rhodopsin/cytochrome b562 – Cryo EM<br />
Line 142: Line 380:
**[[6os9]] – hTDN + NTR1 + JMV449 + scFv – Cryo EM<br />
**[[6os9]] – hTDN + NTR1 + JMV449 + scFv – Cryo EM<br />
-
**[[6lfm]], [[6lfo]] – hTDN + chemokine receptor + IL8 + scFv – Cryo EM<br />
 
**[[7l1v]] – hTDN + orexin receptor + scFv + nanobody – Cryo EM<br />
**[[7l1v]] – hTDN + orexin receptor + scFv + nanobody – Cryo EM<br />
-
**[[7sbf]], [[7scg]], [[7u2l]] – hTDN + mu opioid receptor + scFv + ligand – Cryo EM<br />
+
**[[7qvm]], [[7ryc]] – hTDN + oxytocin receptor + scFv + oxytocin peptide – Cryo EM<br />
-
**[[7dfl]] – hTDN + histamin receptor + scFv + histamin – Cryo EM<br />
+
-
**[[7ryc]] – hTDN + oxytocin receptor + scFv + oxytocin – Cryo EM<br />
+
-
**[[7vl9]], [[7vla]] – hTDN + chemokine receptor + scFv + CCL15 – Cryo EM<br />
+
-
**[[7t6b]], [[7wf7]] – hTDN + sphingosine receptor + scFv + sphingosine – Cryo EM<br />
+
-
**[[7eo2]], [[7eo4]] – hTDN + sphingosine receptor + scFv + agonist – Cryo EM<br />
+
-
**[[7f2o]] – hTDN + bradykinin receptor + scFv + polypeptide – Cryo EM<br />
+
**[[7aue]] – hTDN + melatonin receptor + scFv + aminoserine – Cryo EM<br />
**[[7aue]] – hTDN + melatonin receptor + scFv + aminoserine – Cryo EM<br />
**[[7vgy]], [[7vgz]] – hTDN + melatonin receptor + scFv + cholesterol + drug – Cryo EM<br />
**[[7vgy]], [[7vgz]] – hTDN + melatonin receptor + scFv + cholesterol + drug – Cryo EM<br />
-
**[[7w53]], [[7w55]], [[7w56]], [[7w57]] – hTDN + neuromedin receptor + scFv + neuromedin – Cryo EM<br />
+
**[[7w53]], [[7w55]], [[7w56]], [[7w57]], [[8h0p]] – hTDN + neuromedin receptor + scFv + neuromedin – Cryo EM<br />
-
**[[6xox]], [[7rg9]] – hTDN + glucagon-like peptide receptor + scFv + nanobody – Cryo EM<br />
+
-
**[[7rgp]] – hTDN + glucagon-like peptide receptor + scFv + nanobody + polypeptide – Cryo EM<br />
+
**[[7dw9]] – hTDN + vasopressin receptor + scFv + nanobody + polypeptide – Cryo EM<br />
**[[7dw9]] – hTDN + vasopressin receptor + scFv + nanobody + polypeptide – Cryo EM<br />
-
**[[7ezk]], [[7ezm]] – hTDN + cholecystokinin receptor + cholecystokinin + scFv – Cryo EM<br />
+
**[[7w3z]], [[8h0q]] – hTDN + gastrin-releasing peptide receptor + gastrin-releasing peptide + scFv – Cryo EM<br />
-
**[[7f8w]] – hTDN + cholecystokinin receptor + gastrin + scFv – Cryo EM<br />
+
**[[7w40]] – hTDN + gastrin-releasing peptide receptor + peptide agonist + scFv – Cryo EM<br />
-
**[[7ej0]], [[7ej8]], [[7eja]], [[7ejk]] – hTDN + adrenergic receptor + scFv + drug – Cryo EM<br />
+
-
**[[7rkx]], [[7rky]] – hTDN + GPC receptor + scFv + GDP – Cryo EM<br />
+
-
**[[7rkf]], [[7rkm]], [[7rkn]] – hTDN + GPC receptor + scFv + fractalkine – Cryo EM<br />
+
-
**[[7ejx]], [[7vug]] – hTDN + GPC receptor + scFv + ligand – Cryo EM<br />
+
**[[7na7]], [[7w2z]] – hTDN + ghrelin receptor + scFv + gherlin – Cryo EM<br />
**[[7na7]], [[7w2z]] – hTDN + ghrelin receptor + scFv + gherlin – Cryo EM<br />
**[[7e9g]] – hTDN + glutamate receptor + scFv + DN13 – Cryo EM<br />
**[[7e9g]] – hTDN + glutamate receptor + scFv + DN13 – Cryo EM<br />
**[[7p00]], [[7p02]] – hTDN + substance P receptor + scFv + substance P – Cryo EM<br />
**[[7p00]], [[7p02]] – hTDN + substance P receptor + scFv + substance P – Cryo EM<br />
-
**[[7t11]] – hTDN + somatostatin receptor + scFv + octreotide – Cryo EM<br />
+
**[[7w0l]], [[7w0m]] – hTDN + apelin receptor + pyrimidine derivative + scFv – Cryo EM<br />
-
**[[7t10]] – hTDN + somatostatin receptor + scFv + somatostatin – Cryo EM<br />
+
**[[7w0n]], [[7w0o]], [[7w0p]] – hTDN + apelin receptor + apelin peptide + scFv – Cryo EM<br />
-
**[[7s8o]] – hTDN + MAS-related receptor + scFv + ligand – Cryo EM<br />
+
**[[7x9a]], [[7x9b]], [[7yon]], [[7yoo]] – hTDN + neuropeptide receptor + scFv + neuropeptide – Cryo EM<br />
-
**[[7vdh]], [[7vdl]], [[7vdm]], [[7vuy]], [[7vuz]], [[7vv3]], [[7vv5]] – hTDN + MAS-related receptor + scFv + cholesterol + ligand – Cryo EM<br />
+
**[[7try]], [[7ts0]] – hTDN + CRFR-2 + urocortin + scFv – Cryo EM<br />
-
**[[7s8m]] – hTDN + MAS-related receptor + scFv + cortistatin – Cryo EM<br />
+
**[[8fmz]], [[8fn0]], [[8fn1]] – hTDN + neurotensin receptor + neurotensin + scFv – Cryo EM<br />
-
**[[7v6a]] – hTDN + muscarinic acetylcholine receptor + scFv + piperidine derivative – Cryo EM<br />
+
**[[8hcx]], [[8hcq]], [[8hbd]] – hTDN + endothelin receptor + endothelin peptide + scFv – Cryo EM<br />
-
**[[7jvr]] – hTDN + dopamine receptor + ligand + scFv – Cryo EM<br />
+
**[[7wkd]], [[7x1t]] – hTDN + thyroliberin receptor + peptide agonist + scFv – Cryo EM<br />
 +
**[[8h2g]], [[8jii]], [[8jil]] – hTDN + hydroxycarboxylic acid receptor + niacin + scFv – Cryo EM<br />
 +
**[[8jhy]] – hTDN + hydroxycarboxylic acid receptor + agonist + scFv – Cryo EM<br />
 +
**[[8ghv]], [[8guq]], [[8gut]] – hTDN + cannabinoid receptor + activator + scFv – Cryo EM<br />
 +
**[[7ykd]] – hTDN + chemerin-like receptor + chemerin + scFv – Cryo EM<br />**[[8h8j]] – hTDN + kynurenic acid receptor + drug + scFv – Cryo EM<br />
 +
**[[8f7x]] – hTDN + nociceptin receptor + nanobody + nociceptin peptide – Cryo EM<br />
 +
**[[8ejc]], [[8ejk]] – hTDN + free fatty acid receptor + scFv + ligand – Cryo EM<br />
 +
**[[7sqo]] – hTDN + orexin receptor + scFv + ligand – Cryo EM<br />
 +
**[[7ew3]], [[7vie]], [[7vig]], [[7vih]] – hTDN + S1P receptor + S1P + scFv – Cryo EM<br />
 +
**[[7vif]], [[7vig]], [[7vih]], [[7ew2]], [[7ew4]], [[7ew7]] – hTDN + S1P receptor + scFv + agonist – Cryo EM<br />
 +
**[[7evy]], [[7evz]], [[7ew0]], [[7ew1]] – hTDN + S1P receptor + scFv + drug – Cryo EM<br />
 +
**[[7xow]] – hTDN + CCK-B receptor + gastrin peptide + scFv – Cryo EM<br />
 +
**[[7xwo]] – hTDN + neurokinin receptor + scFv + neurokinin peptide – Cryo EM<br />
*Transducin-α+βγ quaternary complex with nanobody
*Transducin-α+βγ quaternary complex with nanobody
**[[6pb1]], [[6pb0]] – hTDN + CRFR-2 + urocortin + nanobody – Cryo EM<br />
**[[6pb1]], [[6pb0]] – hTDN + CRFR-2 + urocortin + nanobody – Cryo EM<br />
-
**[[6niy]], [[6e3y]], [[7tyi]], [[7tyn]], [[7tyo]] – hTDN + calcitonin receptor + calcitonin + nanobody – Cryo EM<br />
+
**[[6vn7]], [[8e3y]] – hTDN + VIP-1 receptor + PACAP + nanobody – Cryo EM<br />
-
**[[7tyw]] – hTDN + calcitonin receptor + calcitonin + receptor activity-modifying protein + nanobody – Cryo EM<br />
+
**[[7vqx]], [[7wbj]] – hTDN + VIP-2 receptor + PACAP + nanobody – Cryo EM<br />
-
**[[6vn7]] – hTDN + VIP-1 receptor + PACAP + nanobody – Cryo EM<br />
+
**[[8e3z]] – hTDN + VIP-1 receptor + VIP + nanobody – Cryo EM<br />
 +
**[[8e3x]] – hTDN + PACAP receptor + PACAP + nanobody – Cryo EM<br />
**[[6m1h]] – hTDN + PAC1 receptor + maxadilan + nanobody – Cryo EM<br />
**[[6m1h]] – hTDN + PAC1 receptor + maxadilan + nanobody – Cryo EM<br />
**[[7d3s]], [[6wi9]], [[6wzg]] – hTDN + secretin receptor + secretin + nanobody – Cryo EM<br />
**[[7d3s]], [[6wi9]], [[6wzg]] – hTDN + secretin receptor + secretin + nanobody – Cryo EM<br />
-
**[[6whc]] – hTDN + glucagon receptor + dual-agonist peptide + nanobody – Cryo EM<br />
 
-
**[[6lmk]], [[6lml]], [[6x1a]], [[6x19]], [[6x18]], [[6wpw]], [[5vai]], [[6vcb]] – hTDN + glucagon receptor + glucagon + nanobody – Cryo EM<br />
 
**[[7cz5]] – hTDN + growth hormone-releasing hormone receptor + somatoliberin + nanobody – Cryo EM<br />
**[[7cz5]] – hTDN + growth hormone-releasing hormone receptor + somatoliberin + nanobody – Cryo EM<br />
**[[6uva]], [[6uun]], [[6uus]] – hTDN + receptor activity-modifying protein + ADM2 + CGRP receptor + nanobody – Cryo EM<br />
**[[6uva]], [[6uun]], [[6uus]] – hTDN + receptor activity-modifying protein + ADM2 + CGRP receptor + nanobody – Cryo EM<br />
**[[6b3j]] – hTDN + GLP-1R + exendin-p5 + nanobody – Cryo EM<br />
**[[6b3j]] – hTDN + GLP-1R + exendin-p5 + nanobody – Cryo EM<br />
-
**[[7wq3]], [[7wq4]] – hTDN + galanin receptor + nanobody + galanin – Cryo EM<br />
+
**[[7x8s]], [[8jip]], [[8jir]], [[8jis]] – hTDN + GLP-1R + peptide agonist + nanobody – Cryo EM<br />
-
**[[7f53]], [[7f54]], [[7f55]], [[7piu]], [[7piv]] – hTDN + melanocortin receptor + nanobody + peptide agonist – Cryo EM<br />
+
**[[7x8r]] – hTDN + GLP-1R + agonist + nanobody – Cryo EM<br />
**[[7vgx]] – hTDN + neuropeptide receptor + nanobody + neuropeptide agonist – Cryo EM<br />
**[[7vgx]] – hTDN + neuropeptide receptor + nanobody + neuropeptide agonist – Cryo EM<br />
**[[7dty]] – hTDN + insulinotropic receptor + gastric inhibitory polypeptide + nanobody – Cryo EM<br />
**[[7dty]] – hTDN + insulinotropic receptor + gastric inhibitory polypeptide + nanobody – Cryo EM<br />
**[[7bb6]], [[7bb7]] – hTDN + vasopressin receptor + vasopressin + nanobody – Cryo EM<br/>
**[[7bb6]], [[7bb7]] – hTDN + vasopressin receptor + vasopressin + nanobody – Cryo EM<br/>
-
**[[7ki0]], [[7ki1]], [[7d68]], [[7rtb]], [[7s1m]] – hTDN + glucagon-like peptide receptor + nanobody + glucagon derivative – Cryo EM<br />
 
-
**[[7lll]] – hTDN + glucagon-like peptide receptor + nanobody + exendin – Cryo EM<br />
 
-
**[[7fim]], [[7lly]], [[7v35]], [[7vbh]], [[7vbi]] – hTDN + glucagon-like peptide receptor + nanobody + polypeptide – Cryo EM<br />
 
-
**[[7mbx]] – hTDN + cholecystokinin receptor + cholecystokinin + nanobody – Cryo EM<br />
 
-
**[[7bz2]], [[7dhi]], [[7dhr]] – hTDN + adrenergic receptor + nanobody + agonist – Cryo EM<br />
 
-
**[[7xjh]], [[7xji]] – hTDN + adrenergic receptor + nanobody + drug – Cryo EM<br />
 
-
**[[7vuh]], [[7vui]], [[7vuj]] – hTDN + GPC receptor + nanobody + ligand – Cryo EM<br />
 
**[[7f9y]], [[7f9z]], [[7na8]] – hTDN + ghrelin receptor + nanobody + pyrazole derivative – Cryo EM<br />
**[[7f9y]], [[7f9z]], [[7na8]] – hTDN + ghrelin receptor + nanobody + pyrazole derivative – Cryo EM<br />
-
P receptor + scFv + substance P – Cryo EM<br />
 
**[[7rmg]], [[7rmh]], [[7rmi]] – hTDN + substance P receptor + nanobody + substance P – Cryo EM<br />
**[[7rmg]], [[7rmh]], [[7rmi]] – hTDN + substance P receptor + nanobody + substance P – Cryo EM<br />
 +
**[[8u26]] – hTDN + substance P receptor + nanobody + protakichinin peptide – Cryo EM<br />
**[[7v9m]] – hTDN + GHRH receptor + nanobody + somatoliberin – Cryo EM<br />
**[[7v9m]] – hTDN + GHRH receptor + nanobody + somatoliberin – Cryo EM<br />
-
**[[7tyl]] – hTDN + calcitonin receptor + nanobody + amylin peptide – Cryo EM<br />
 
-
**[[7tyf]], [[7tyh]], [[7tyx]], [[7tyy]], [[7tzf]] – hTDN + calcitonin receptor + nanobody + amylin peptide + receptor activity-modifying protein - Cryo EM<br />
 
**[[7fin]], [[7fiy]], [[7ra3]], [[7vab]] – hTDN + GIP receptor + nanobody + polypeptide – Cryo EM<br />
**[[7fin]], [[7fiy]], [[7ra3]], [[7vab]] – hTDN + GIP receptor + nanobody + polypeptide – Cryo EM<br />
-
**[[7cky]], [[7crh]], [[7jv5]], [[7jvp]], [[7jvq]] – hTDN + dopamine receptor + ligand + nanobody – Cryo EM<br />
+
**[[7xou]] – hTDN + CCK-A receptor + nanobody + CCK-8 – Cryo EM<br />
 +
**[[7xtq]] – hTDN + GPC bile acid receptor + pyrimidine derivative + nanobody – Cryo EM<br />
 +
**[[8i2g]] – hTDN + follitropin receptor + nanobody + follitropin + glycoprotein hormone – Cryo EM<br />
*Transducin-α+βγ quaternary complex with scFv and nanobody
*Transducin-α+βγ quaternary complex with scFv and nanobody
**[[7rbt]] – hTDN + GIP receptor + nanobody + scFv + polypeptide – Cryo EM<br />
**[[7rbt]] – hTDN + GIP receptor + nanobody + scFv + polypeptide – Cryo EM<br />
-
**[[7joz]] – hTDN + dopamine receptor + scFv + nanobody <br />
 
-
**[[7wu2]], [[7wu3]], [[7wui]], [[7wuj]] – hTDN + adhesion GPC receptor + scFv + nanobody – Cryo EM<br />
 
-
**[[7ckw]], [[7ckx]], [[7ckz]], [[7ljc]] – hTDN + dopamine receptor + scFv + nanobody – Cryo EM<br />
 
**[[7kh0]] – hTDN + vasopressin receptor + vasopressin + scFv + nanobody – Cryo EM<br />
**[[7kh0]] – hTDN + vasopressin receptor + vasopressin + scFv + nanobody – Cryo EM<br />
Line 220: Line 446:
**[[6qno]] – h/bTDN + antibody + rhodopsin + retinal – Cryo EM<br />
**[[6qno]] – h/bTDN + antibody + rhodopsin + retinal – Cryo EM<br />
**[[6oya]] – bTDN + antibody + rhodopsin + retinal – Cryo EM<br />
**[[6oya]] – bTDN + antibody + rhodopsin + retinal – Cryo EM<br />
- 
}}
}}
[[Category: Topic Page]]
[[Category: Topic Page]]

Revision as of 07:47, 15 January 2024

3D structures of transducin

Updated on 15-January-2024 - For a general description of the protein see Transducin





Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky

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