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1h4l

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[[Image:1h4l.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1h4l| PDB=1h4l | SCENE= }}
{{STRUCTURE_1h4l| PDB=1h4l | SCENE= }}
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'''STRUCTURE AND REGULATION OF THE CDK5-P25(NCK5A) COMPLEX'''
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===STRUCTURE AND REGULATION OF THE CDK5-P25(NCK5A) COMPLEX===
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==Overview==
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CDK5 plays an indispensable role in the central nervous system, and its deregulation is involved in neurodegeneration. We report the crystal structure of a complex between CDK5 and p25, a fragment of the p35 activator. Despite its partial structural similarity with the cyclins, p25 displays an unprecedented mechanism for the regulation of a cyclin-dependent kinase. p25 tethers the unphosphorylated T loop of CDK5 in the active conformation. Residue Ser159, equivalent to Thr160 on CDK2, contributes to the specificity of the CDK5-p35 interaction. Its substitution with threonine prevents p35 binding, while the presence of alanine affects neither binding nor kinase activity. Finally, we provide evidence that the CDK5-p25 complex employs a distinct mechanism from the phospho-CDK2-cyclin A complex to establish substrate specificity.
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The line below this paragraph, {{ABSTRACT_PUBMED_11583627}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11583627 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11583627}}
==About this Structure==
==About this Structure==
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[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:25:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:36:59 2008''

Revision as of 03:37, 1 July 2008

Image:1h4l.png


PDB ID 1h4l

Drag the structure with the mouse to rotate
1h4l, resolution 2.65Å ()
Related: 1lfr
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



STRUCTURE AND REGULATION OF THE CDK5-P25(NCK5A) COMPLEX

Template:ABSTRACT PUBMED 11583627

About this Structure

1H4L is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and regulation of the CDK5-p25(nck5a) complex., Tarricone C, Dhavan R, Peng J, Areces LB, Tsai LH, Musacchio A, Mol Cell. 2001 Sep;8(3):657-69. PMID:11583627

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