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7qie
From Proteopedia
(Difference between revisions)
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==Crystal Structure of Phosphatidylinositol 5-Phosphate 4-Kinase (PI5P4K2C) bound to an allosteric inhibitor== | ==Crystal Structure of Phosphatidylinositol 5-Phosphate 4-Kinase (PI5P4K2C) bound to an allosteric inhibitor== | ||
| - | <StructureSection load='7qie' size='340' side='right'caption='[[7qie]]' scene=''> | + | <StructureSection load='7qie' size='340' side='right'caption='[[7qie]], [[Resolution|resolution]] 2.39Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QIE FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7qie]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QIE FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qie OCA], [https://pdbe.org/7qie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qie RCSB], [https://www.ebi.ac.uk/pdbsum/7qie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qie ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DVF:5-methyl-2-(2-propan-2-ylphenyl)-~{N}-(pyridin-2-ylmethyl)pyrrolo[3,2-d]pyrimidin-4-amine'>DVF</scene></td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/1-phosphatidylinositol-5-phosphate_4-kinase 1-phosphatidylinositol-5-phosphate 4-kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.149 2.7.1.149] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qie OCA], [https://pdbe.org/7qie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qie RCSB], [https://www.ebi.ac.uk/pdbsum/7qie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qie ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/PI42C_HUMAN PI42C_HUMAN]] May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: 1-phosphatidylinositol-5-phosphate 4-kinase]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Howard | + | [[Category: Howard, T D]] |
| - | [[Category: Ogg | + | [[Category: Ogg, D T]] |
| + | [[Category: Allosteric binding]] | ||
| + | [[Category: Lipid kinase]] | ||
| + | [[Category: Non-atp-competitive inhibitor]] | ||
| + | [[Category: Phosphatidylinositol 5-phosphate]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 05:09, 10 August 2022
Crystal Structure of Phosphatidylinositol 5-Phosphate 4-Kinase (PI5P4K2C) bound to an allosteric inhibitor
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