7yyh

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Current revision (12:40, 17 July 2024) (edit) (undo)
 
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==Structure of the human CCANdeltaT CENP-A alpha-satellite complex==
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<StructureSection load='7yyh' size='340' side='right'caption='[[7yyh]]' scene=''>
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<StructureSection load='7yyh' size='340' side='right'caption='[[7yyh]], [[Resolution|resolution]] 8.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7yyh]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YYH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YYH FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yyh OCA], [https://pdbe.org/7yyh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yyh RCSB], [https://www.ebi.ac.uk/pdbsum/7yyh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yyh ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 8.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yyh OCA], [https://pdbe.org/7yyh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yyh RCSB], [https://www.ebi.ac.uk/pdbsum/7yyh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yyh ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CENPM_HUMAN CENPM_HUMAN] Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.<ref>PMID:16716197</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Kinetochores assemble onto specialized centromeric CENP-A (centromere protein A) nucleosomes (CENP-A(Nuc)) to mediate attachments between chromosomes and the mitotic spindle. We describe cryo-electron microscopy structures of the human inner kinetochore constitutive centromere associated network (CCAN) complex bound to CENP-A(Nuc) reconstituted onto alpha-satellite DNA. CCAN forms edge-on contacts with CENP-A(Nuc), and a linker DNA segment of the alpha-satellite repeat emerges from the fully wrapped end of the nucleosome to thread through the central CENP-LN channel that tightly grips the DNA. The CENP-TWSX histone-fold module further augments DNA binding and partially wraps the linker DNA in a manner reminiscent of canonical nucleosomes. Our study suggests that the topological entrapment of the linker DNA by CCAN provides a robust mechanism by which kinetochores withstand both pushing and pulling forces exerted by the mitotic spindle.
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Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome.,Yatskevich S, Muir KW, Bellini D, Zhang Z, Yang J, Tischer T, Predin M, Dendooven T, McLaughlin SH, Barford D Science. 2022 May 20;376(6595):844-852. doi: 10.1126/science.abn3810. Epub 2022 , Apr 14. PMID:35420891<ref>PMID:35420891</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7yyh" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Centromere protein 3D structure|Centromere protein 3D structure]]
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*[[Histone 3D structures|Histone 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: Barford D]]
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[[Category: Bellini D]]
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[[Category: Dendooven T]]
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[[Category: McLaughlin SH]]
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[[Category: Muir KW]]
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[[Category: Predin M]]
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[[Category: Tischer T]]
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[[Category: Yang J]]
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[[Category: Yatskevich S]]
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[[Category: Zhang Z]]

Current revision

Structure of the human CCANdeltaT CENP-A alpha-satellite complex

PDB ID 7yyh

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