3omj
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3omj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OMJ FirstGlance]. <br> | <table><tr><td colspan='2'>[[3omj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OMJ FirstGlance]. <br> | ||
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1P2:(23R,52R)-23,52-DIAMINO-5,11,17,28,34,40,46,57-OCTAMETHYL-2,5,8,11,14,17,20,25,28,31,34,37,40,43,46,49,54,57,60,64-ICOSAAZANONACYCLO[54.2.1.1~4,7~.1~10,13~.1~16,19~.1~27,30~.1~33,36~.1~39,42~.1~45,48~]HEXAHEXACONTA-1(58),4(66),6,10(65),12,16(64),18,27(63),29,33(62),35,39(61),41,45(60),47,56(59)-HEXADECAENE-3,9,15,21,26,32,38,44,50,55-DECONE'>1P2</scene>, | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.95Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1P2:(23R,52R)-23,52-DIAMINO-5,11,17,28,34,40,46,57-OCTAMETHYL-2,5,8,11,14,17,20,25,28,31,34,37,40,43,46,49,54,57,60,64-ICOSAAZANONACYCLO[54.2.1.1~4,7~.1~10,13~.1~16,19~.1~27,30~.1~33,36~.1~39,42~.1~45,48~]HEXAHEXACONTA-1(58),4(66),6,10(65),12,16(64),18,27(63),29,33(62),35,39(61),41,45(60),47,56(59)-HEXADECAENE-3,9,15,21,26,32,38,44,50,55-DECONE'>1P2</scene>, <scene name='pdbligand=C38:5-IODO-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>C38</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3omj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3omj OCA], [https://pdbe.org/3omj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3omj RCSB], [https://www.ebi.ac.uk/pdbsum/3omj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3omj ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3omj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3omj OCA], [https://pdbe.org/3omj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3omj RCSB], [https://www.ebi.ac.uk/pdbsum/3omj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3omj ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Pyrrole-imidazole polyamides are a class of small molecules that can be programmed to bind a broad repertoire of DNA sequences, disrupt transcription factor-DNA interfaces, and modulate gene expression pathways in cell culture experiments. In this paper we describe a high-resolution X-ray crystal structure of a beta-amino turn-linked eight-ring cyclic Py-Im polyamide bound to the central six base pairs of the sequence d(5'-CCAGTACTGG-3')(2), revealing significant modulation of DNA shape. We compare the DNA structural perturbations induced by DNA-binding transcripton factors, androgen receptor and glucocorticoid receptor, in the major groove to those induced by cyclic polyamide binding in the minor groove. The cyclic polyamide is an allosteric modulator that perturbs the DNA structure in such a way that nuclear receptor protein binding is no longer compatible. This allosteric perturbation of the DNA helix provides a molecular basis for disruption of transcription factor-DNA interfaces by small molecules, a minimum step in chemical control of gene networks. | ||
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| - | Structural basis for cyclic Py-Im polyamide allosteric inhibition of nuclear receptor binding.,Chenoweth DM, Dervan PB J Am Chem Soc. 2010 Oct 20;132(41):14521-9. PMID:20812704<ref>PMID:20812704</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 3omj" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Chenoweth | + | [[Category: Chenoweth DM]] |
| - | + | ||
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Current revision
Structural Basis for Cyclic Py-Im Polyamide Allosteric Inhibition of Nuclear Receptor Binding
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