1h5w

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{{Seed}}
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{{STRUCTURE_1h5w| PDB=1h5w | SCENE= }}
{{STRUCTURE_1h5w| PDB=1h5w | SCENE= }}
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'''2.1A BACTERIOPHAGE PHI-29 CONNECTOR'''
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===2.1A BACTERIOPHAGE PHI-29 CONNECTOR===
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==Overview==
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The three-dimensional crystal structure of the bacteriophage phi29 connector has been solved and refined to 2.1A resolution. This 422 kDa oligomeric protein connects the head of the phage to its tail and translocates the DNA into the prohead during packaging. Each monomer has an elongated shape and is composed of a central, mainly alpha-helical domain that includes a three-helix bundle, a distal alpha/beta domain and a proximal six-stranded SH3-like domain. The protomers assemble into a 12-mer, propeller-like, super-structure with a 35 A wide central channel. The surface of the channel is mainly electronegative, but it includes two lysine rings 20 A apart. On the external surface of the particle a hydrophobic belt extends to the concave area below the SH3-like domain, which forms a crown that retains the particle in the head. The lipophilic belt contacts the non-matching symmetry vertex of the capsid and forms a bearing for the connector rotation. The structure suggests a translocation mechanism in which the longitudinal displacement of the DNA along its axis is coupled to connector spinning.
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The line below this paragraph, {{ABSTRACT_PUBMED_11812138}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11812138 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11812138}}
==About this Structure==
==About this Structure==
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[[Category: Sh3-like]]
[[Category: Sh3-like]]
[[Category: Virus]]
[[Category: Virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:28:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:40:39 2008''

Revision as of 03:40, 1 July 2008

Image:1h5w.png

Template:STRUCTURE 1h5w

2.1A BACTERIOPHAGE PHI-29 CONNECTOR

Template:ABSTRACT PUBMED 11812138

About this Structure

1H5W is a Single protein structure of sequence from Bacillus phage phi29. Full crystallographic information is available from OCA.

Reference

Detailed architecture of a DNA translocating machine: the high-resolution structure of the bacteriophage phi29 connector particle., Guasch A, Pous J, Ibarra B, Gomis-Ruth FX, Valpuesta JM, Sousa N, Carrascosa JL, Coll M, J Mol Biol. 2002 Jan 25;315(4):663-76. PMID:11812138

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