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1h5y

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[[Image:1h5y.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1h5y| PDB=1h5y | SCENE= }}
{{STRUCTURE_1h5y| PDB=1h5y | SCENE= }}
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'''HISF PROTEIN FROM PYROBACULUM AEROPHILUM'''
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===HISF PROTEIN FROM PYROBACULUM AEROPHILUM===
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==Overview==
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HisF (imidazole glycerol phosphate synthase) is an important branch-point enzyme in the histidine biosynthetic pathway of microorganisms. Because of its potential relevance for structure-based drug design, the crystal structure of HisF from the hyperthermophilic archaeon Pyrobaculum aerophilum has been determined. The structure was determined by molecular replacement and refined at 2.0 A resolution to a crystallographic R factor of 20.6% and a free R of 22.7%. The structure adopts a classic (beta/alpha)(8) barrel fold and has networks of surface salt bridges that may contribute to thermostability. The active site is marked out by the presence of two bound phosphate ions and two glycerol molecules that delineate a long groove at one end of the (beta/alpha)(8) barrel. The two phosphate ions, 17 A apart, are bound to sequence-conserved structural motifs that seem likely to provide much of the specificity for the two phosphate groups of the HisF substrate. The two glycerol molecules bind in the vicinity of other sequence-conserved residues that are likely to be involved in binding and/or catalysis. Comparisons with the homologous HisF from Thermatoga maritima reveal a displaced loop that may serve as a lid over the active site.
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(as it appears on PubMed at http://www.pubmed.gov), where 11679715 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11679715}}
==About this Structure==
==About this Structure==
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[[Category: Histidine biosynthesis]]
[[Category: Histidine biosynthesis]]
[[Category: Tim-barrel]]
[[Category: Tim-barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:28:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:40:43 2008''

Revision as of 03:40, 1 July 2008

Image:1h5y.png

Template:STRUCTURE 1h5y

HISF PROTEIN FROM PYROBACULUM AEROPHILUM

Template:ABSTRACT PUBMED 11679715

About this Structure

1H5Y is a Single protein structure of sequence from Pyrobaculum aerophilum. Full crystallographic information is available from OCA.

Reference

Structure of HisF, a histidine biosynthetic protein from Pyrobaculum aerophilum., Banfield MJ, Lott JS, Arcus VL, McCarthy AA, Baker EN, Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt 11):1518-25. Epub 2001, Oct 25. PMID:11679715

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