3p49

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Current revision (10:38, 21 February 2024) (edit) (undo)
 
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<StructureSection load='3p49' size='340' side='right'caption='[[3p49]], [[Resolution|resolution]] 3.55&Aring;' scene=''>
<StructureSection load='3p49' size='340' side='right'caption='[[3p49]], [[Resolution|resolution]] 3.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3p49]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P49 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3p49]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusobacterium_nucleatum_subsp._polymorphum Fusobacterium nucleatum subsp. polymorphum] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P49 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.55&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p49 OCA], [https://pdbe.org/3p49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p49 RCSB], [https://www.ebi.ac.uk/pdbsum/3p49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p49 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p49 OCA], [https://pdbe.org/3p49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p49 RCSB], [https://www.ebi.ac.uk/pdbsum/3p49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p49 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN]] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref>
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[https://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The glycine riboswitch regulates gene expression through the cooperative recognition of its amino acid ligand by a tandem pair of aptamers. A 3.6 A crystal structure of the tandem riboswitch from the glycine permease operon of Fusobacterium nucleatum reveals the glycine binding sites and an extensive network of interactions, largely mediated by asymmetric A-minor contacts, that serve to communicate ligand binding status between the aptamers. These interactions provide a structural basis for how the glycine riboswitch cooperatively regulates gene expression.
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Structural basis of cooperative ligand binding by the glycine riboswitch.,Butler EB, Xiong Y, Wang J, Strobel SA Chem Biol. 2011 Mar 25;18(3):293-8. PMID:21439473<ref>PMID:21439473</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3p49" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Fusobacterium nucleatum subsp. polymorphum]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Butler, E B]]
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[[Category: Butler EB]]
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[[Category: Strobel, S]]
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[[Category: Strobel S]]
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[[Category: Wang, J]]
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[[Category: Wang J]]
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[[Category: Xiong, Y]]
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[[Category: Xiong Y]]
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[[Category: Cooperative]]
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[[Category: Glycine]]
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[[Category: Riboswitch]]
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[[Category: Rna]]
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[[Category: Rna binding protein-rna complex]]
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Current revision

Crystal Structure of a Glycine Riboswitch from Fusobacterium nucleatum

PDB ID 3p49

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OCA

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