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1h68

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[[Image:1h68.gif|left|200px]]
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[[Image:1h68.png|left|200px]]
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==Overview==
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{{ABSTRACT_11504917}}
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Sensory rhodopsins (SRs) belong to a subfamily of heptahelical transmembrane proteins containing a retinal chromophore. These photoreceptors mediate the cascade of vision in animal eyes and phototaxis in archaebacteria and unicellular flagellated algae. Signal transduction by these photoreceptors occurs by means of transducer proteins. The two archaebacterial sensory rhodopsins SRI and SRII are coupled to the membrane-bound HtrI and HtrII transducer proteins. Activation of these proteins initiates phosphorylation cascades that modulate the flagellar motors, resulting in either attractant (SRI) or repellent (SRII) phototaxis. In addition, transducer-free SRI and SRII were shown to operate as proton pumps, analogous to bacteriorhodopsin. Here, we present the x-ray structure of SRII from Natronobacterium pharaonis (pSRII) at 2.1-A resolution, revealing a unique molecular architecture of the retinal-binding pocket. In particular, the structure of pSRII exhibits a largely unbent conformation of the retinal (as compared with bacteriorhodopsin and halorhodopsin), a hydroxyl group of Thr-204 in the vicinity of the Schiff base, and an outward orientation of the guanidinium group of Arg-72. Furthermore, the structure reveals a putative chloride ion that is coupled to the Schiff base by means of a hydrogen-bond network and a unique, positively charged surface patch for a probable interaction with HtrII. The high-resolution structure of pSRII provides a structural basis to elucidate the mechanisms of phototransduction and color tuning.
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==About this Structure==
==About this Structure==
1H68 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Natronomonas_pharaonis Natronomonas pharaonis]. The following page contains interesting information on the relation of 1H68 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb27_1.html Bacteriorhodopsin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H68 OCA].
1H68 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Natronomonas_pharaonis Natronomonas pharaonis]. The following page contains interesting information on the relation of 1H68 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb27_1.html Bacteriorhodopsin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H68 OCA].
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==Reference==
 
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X-ray structure of sensory rhodopsin II at 2.1-A resolution., Royant A, Nollert P, Edman K, Neutze R, Landau EM, Pebay-Peyroula E, Navarro J, Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10131-6. Epub 2001 Aug 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11504917 11504917]
 
[[Category: Bacteriorhodopsin]]
[[Category: Bacteriorhodopsin]]
[[Category: Natronomonas pharaonis]]
[[Category: Natronomonas pharaonis]]
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[[Category: Photoreceptor]]
[[Category: Photoreceptor]]
[[Category: Phototaxis]]
[[Category: Phototaxis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:29:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:27:10 2008''

Revision as of 14:27, 26 June 2008

Image:1h68.png

Template:STRUCTURE 1h68

SENSORY RHODOPSIN II


Template:ABSTRACT 11504917

About this Structure

1H68 is a Single protein structure of sequence from Natronomonas pharaonis. The following page contains interesting information on the relation of 1H68 with [Bacteriorhodopsin]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:27:10 2008

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