1h6g

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{{Seed}}
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{{STRUCTURE_1h6g| PDB=1h6g | SCENE= }}
{{STRUCTURE_1h6g| PDB=1h6g | SCENE= }}
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'''ALPHA-CATENIN M-DOMAIN'''
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===ALPHA-CATENIN M-DOMAIN===
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==Overview==
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The cytoskeletal protein alpha-catenin, which shares structural similarity with vinculin, is required for cadherin-mediated cell adhesion, and functions to modulate cell adhesive strength and to link the cadherins to the actin-based cytoskeleton. Here we describe the crystal structure of a region of alpha-catenin (residues 377-633) termed the M-fragment. The M-fragment is composed of a tandem repeat of two antiparallel four-helix bundles of virtually identical architectures that are related in structure to the dimerization domain of alpha-catenin and the tail region of vinculin. These results suggest that alpha-catenin is composed of repeating antiparallel helical domains. The region of alpha-catenin previously defined as an adhesion modulation domain corresponds to the C-terminal four-helix bundle of the M-fragment, and in the crystal lattice these domains exist as dimers. Evidence for dimerization of the M-fragment of alpha-catenin in solution was detected by chemical cross-linking experiments. The tendency of the adhesion modulation domain to form dimers may explain its biological activity of promoting cell-cell adhesiveness by inducing lateral dimerization of the associated cadherin molecule.
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(as it appears on PubMed at http://www.pubmed.gov), where 11447106 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11447106}}
==About this Structure==
==About this Structure==
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[[Category: Alpha-catenin]]
[[Category: Alpha-catenin]]
[[Category: Cytoskeleton]]
[[Category: Cytoskeleton]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:29:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:42:10 2008''

Revision as of 03:42, 1 July 2008

Image:1h6g.png

Template:STRUCTURE 1h6g

ALPHA-CATENIN M-DOMAIN

Template:ABSTRACT PUBMED 11447106

About this Structure

1H6G is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the M-fragment of alpha-catenin: implications for modulation of cell adhesion., Yang J, Dokurno P, Tonks NK, Barford D, EMBO J. 2001 Jul 16;20(14):3645-56. PMID:11447106

Page seeded by OCA on Tue Jul 1 06:42:10 2008

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