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1h6i

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[[Image:1h6i.gif|left|200px]]
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{{STRUCTURE_1h6i| PDB=1h6i | SCENE= }}
{{STRUCTURE_1h6i| PDB=1h6i | SCENE= }}
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'''A REFINED STRUCTURE OF HUMAN AQUAPORIN 1'''
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===A REFINED STRUCTURE OF HUMAN AQUAPORIN 1===
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==Overview==
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A refined structure of the human water channel aquaporin-1 is presented. The model rests on the high resolution X-ray structure of the homologous bacterial glycerol transporter GlpF, electron crystallographic data at 3.8 A resolution and a multiple sequence alignment of the aquaporin superfamily. The crystallographic R and free R values (36.7% and 37.8%) for the refined structure are significantly lower than for previous models. Improved geometry and enhanced stability in molecular dynamics simulations demonstrate a significant improvement of the aquaporin-1 structure. Comparison with previous aquaporin-1 models shows significant differences, not only in the loop regions, but also in the core of the water channel.
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(as it appears on PubMed at http://www.pubmed.gov), where 11532455 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11532455}}
==About this Structure==
==About this Structure==
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[[Category: Two-dimensional crystal]]
[[Category: Two-dimensional crystal]]
[[Category: Water channel]]
[[Category: Water channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:29:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:42:14 2008''

Revision as of 03:42, 1 July 2008

Image:1h6i.png

Template:STRUCTURE 1h6i

A REFINED STRUCTURE OF HUMAN AQUAPORIN 1

Template:ABSTRACT PUBMED 11532455

About this Structure

1H6I is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A refined structure of human aquaporin-1., de Groot BL, Engel A, Grubmuller H, FEBS Lett. 2001 Aug 31;504(3):206-11. PMID:11532455

Page seeded by OCA on Tue Jul 1 06:42:14 2008

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