1h6h

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[[Image:1h6h.gif|left|200px]]
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{{Seed}}
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[[Image:1h6h.png|left|200px]]
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{{STRUCTURE_1h6h| PDB=1h6h | SCENE= }}
{{STRUCTURE_1h6h| PDB=1h6h | SCENE= }}
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'''STRUCTURE OF THE PX DOMAIN FROM P40PHOX BOUND TO PHOSPHATIDYLINOSITOL 3-PHOSPHATE'''
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===STRUCTURE OF THE PX DOMAIN FROM P40PHOX BOUND TO PHOSPHATIDYLINOSITOL 3-PHOSPHATE===
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==Overview==
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More than 50 human proteins with a wide range of functions have a 120 residue phosphoinositide binding module known as the PX domain. The 1.7 A X-ray crystal structure of the PX domain from the p40(phox) subunit of NADPH oxidase bound to PtdIns(3)P shows that the PX domain embraces the 3-phosphate on one side of a water-filled, positively charged pocket and reveals how 3-phosphoinositide specificity is achieved. A chronic granulomatous disease (CGD)-associated mutation in the p47(phox) PX domain that abrogates PtdIns(3)P binding maps to a conserved Arg that does not directly interact with the phosphoinositide but instead appears to stabilize a critical lipid binding loop. The SH3 domain present in the full-length protein does not affect soluble PtdIns(3)P binding to the p40(phox) PX domain.
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The line below this paragraph, {{ABSTRACT_PUBMED_11684018}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11684018 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11684018}}
==About this Structure==
==About this Structure==
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[[Category: Williams, R L.]]
[[Category: Williams, R L.]]
[[Category: Px domain]]
[[Category: Px domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:29:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:42:15 2008''

Revision as of 03:42, 1 July 2008

Image:1h6h.png

Template:STRUCTURE 1h6h

STRUCTURE OF THE PX DOMAIN FROM P40PHOX BOUND TO PHOSPHATIDYLINOSITOL 3-PHOSPHATE

Template:ABSTRACT PUBMED 11684018

About this Structure

1H6H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate., Bravo J, Karathanassis D, Pacold CM, Pacold ME, Ellson CD, Anderson KE, Butler PJ, Lavenir I, Perisic O, Hawkins PT, Stephens L, Williams RL, Mol Cell. 2001 Oct;8(4):829-39. PMID:11684018

Page seeded by OCA on Tue Jul 1 06:42:15 2008

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