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1h6k

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{{STRUCTURE_1h6k| PDB=1h6k | SCENE= }}
{{STRUCTURE_1h6k| PDB=1h6k | SCENE= }}
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'''NUCLEAR CAP BINDING COMPLEX'''
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===NUCLEAR CAP BINDING COMPLEX===
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==Overview==
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The heterodimeric nuclear cap binding complex (CBC) binds to 5'-capped polymerase II transcripts. It enhances the efficiency of several mRNA maturation steps and is essential for U snRNA nuclear export in multicellular eukaryotes. The 2A crystal structure of human CBC shows that the large subunit, CBP80, comprises three domains, each containing consecutive helical hairpins and resembling the so-called MIF4G domain found in several other proteins involved in RNA metabolism. The small subunit, CPB20, has an RNP fold and associates with the second and third domains of CBP80. Site-directed mutagenesis revealed 4 residues of CBP20 which are critical for cap binding. A model for cap binding is proposed based on these results and the known mode of binding of RNA to RNP domains.
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(as it appears on PubMed at http://www.pubmed.gov), where 11545740 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11545740}}
==About this Structure==
==About this Structure==
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[[Category: Rna maturation]]
[[Category: Rna maturation]]
[[Category: Rnp domain]]
[[Category: Rnp domain]]
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Revision as of 03:42, 1 July 2008

Image:1h6k.png

Template:STRUCTURE 1h6k

NUCLEAR CAP BINDING COMPLEX

Template:ABSTRACT PUBMED 11545740

About this Structure

1H6K is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the human nuclear cap binding complex., Mazza C, Ohno M, Segref A, Mattaj IW, Cusack S, Mol Cell. 2001 Aug;8(2):383-96. PMID:11545740

Page seeded by OCA on Tue Jul 1 06:42:32 2008

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