1h6q

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{{STRUCTURE_1h6q| PDB=1h6q | SCENE= }}
{{STRUCTURE_1h6q| PDB=1h6q | SCENE= }}
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'''TRANSLATIONALLY CONTROLLED TUMOR-ASSOCIATED PROTEIN P23FYP FROM SCHIZOSACCHAROMYCES POMBE'''
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===TRANSLATIONALLY CONTROLLED TUMOR-ASSOCIATED PROTEIN P23FYP FROM SCHIZOSACCHAROMYCES POMBE===
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==Overview==
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The translationally controlled tumor-associated proteins (TCTPs) are a highly conserved and abundantly expressed family of eukaryotic proteins that are implicated in both cell growth and the human acute allergic response but whose intracellular biochemical function has remained elusive. We report here the solution structure of the TCTP from Schizosaccharomyces pombe, which, on the basis of sequence homology, defines the fold of the entire family. We show that TCTPs form a structural superfamily with the Mss4/Dss4 family of proteins, which bind to the GDP/GTP free form of Rab proteins (members of the Ras superfamily) and have been termed guanine nucleotide-free chaperones (GFCs). Mss4 also acts as a relatively inefficient guanine nucleotide exchange factor (GEF). We further show that the Rab protein binding site on Mss4 coincides with the region of highest sequence conservation in the TCTP family. This is the first link to any other family of proteins that has been established for the TCTP family and suggests the presence of a GFC/GEF at extremely high abundance in eukaryotic cells.
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(as it appears on PubMed at http://www.pubmed.gov), where 11473261 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11473261}}
==About this Structure==
==About this Structure==
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1H6Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H6Q OCA].
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1H6Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H6Q OCA].
==Reference==
==Reference==
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[[Category: Function unknown]]
[[Category: Function unknown]]
[[Category: Tumor-associated protein]]
[[Category: Tumor-associated protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:30:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:43:00 2008''

Revision as of 03:43, 1 July 2008

Image:1h6q.png

Template:STRUCTURE 1h6q

TRANSLATIONALLY CONTROLLED TUMOR-ASSOCIATED PROTEIN P23FYP FROM SCHIZOSACCHAROMYCES POMBE

Template:ABSTRACT PUBMED 11473261

About this Structure

1H6Q is a Single protein structure of sequence from Schizosaccharomyces pombe. Full experimental information is available from OCA.

Reference

Structure of TCTP reveals unexpected relationship with guanine nucleotide-free chaperones., Thaw P, Baxter NJ, Hounslow AM, Price C, Waltho JP, Craven CJ, Nat Struct Biol. 2001 Aug;8(8):701-4. PMID:11473261

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