7ozx

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==Structure of human galactokinase 1 bound with azepan-1-yl(2,6-difluorophenyl)methanone==
==Structure of human galactokinase 1 bound with azepan-1-yl(2,6-difluorophenyl)methanone==
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<StructureSection load='7ozx' size='340' side='right'caption='[[7ozx]]' scene=''>
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<StructureSection load='7ozx' size='340' side='right'caption='[[7ozx]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OZX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OZX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7ozx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OZX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OZX FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ozx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ozx OCA], [https://pdbe.org/7ozx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ozx RCSB], [https://www.ebi.ac.uk/pdbsum/7ozx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ozx ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=HFK:2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1-cyclohexane]-5-one'>HFK</scene>, <scene name='pdbligand=WLJ:(azepan-1-yl)(2,6-difluorophenyl)methanone'>WLJ</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ozx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ozx OCA], [https://pdbe.org/7ozx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ozx RCSB], [https://www.ebi.ac.uk/pdbsum/7ozx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ozx ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/GALK1_HUMAN GALK1_HUMAN] Defects in GALK1 are the cause of galactosemia II (GALCT2) [MIM:[https://omim.org/entry/230200 230200]. Galactosemia II is an autosomal recessive deficiency characterized by congenital cataracts during infancy and presenile cataracts in the adult population. The cataracts are secondary to accumulation of galactitol in the lenses.<ref>PMID:10521295</ref> <ref>PMID:10790206</ref> <ref>PMID:11231902</ref> <ref>PMID:11139256</ref> <ref>PMID:12694189</ref> <ref>PMID:15024738</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/GALK1_HUMAN GALK1_HUMAN] Major enzyme for galactose metabolism.
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==See Also==
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*[[Galactokinase|Galactokinase]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith C]]
[[Category: Arrowsmith C]]

Current revision

Structure of human galactokinase 1 bound with azepan-1-yl(2,6-difluorophenyl)methanone

PDB ID 7ozx

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