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1h6w

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[[Image:1h6w.gif|left|200px]]
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{{STRUCTURE_1h6w| PDB=1h6w | SCENE= }}
{{STRUCTURE_1h6w| PDB=1h6w | SCENE= }}
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'''CRYSTAL STRUCTURE OF A HEAT-AND PROTEASE-STABLE FRAGMENT OF THE BACTERIOPHAGE T4 SHORT FIBRE'''
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===CRYSTAL STRUCTURE OF A HEAT-AND PROTEASE-STABLE FRAGMENT OF THE BACTERIOPHAGE T4 SHORT FIBRE===
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==Overview==
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Adsorption of T4 bacteriophage to the Escherichia coli host cell is mediated by six long and six short tail fibres. After at least three long tail fibres have bound, short tail fibres extend and bind irreversibly to the core region of the host cell lipopolysaccharide (LPS), serving as inextensible stays during penetration of the cell envelope by the tail tube. The short tail fibres consist of a parallel, in-register, trimer of gene product 12 (gp12). The 1.9 A crystal structure of a heat and protease-stable fragment of gp12 reveals three new folds: a central right-handed triple beta-helix, a globular C-terminal domain containing a beta-sandwich and an N-terminal beta-structure reminiscent of but different from the adenovirus triple beta-spiral. The centre of the C-terminal domain shows weak homology to gp11, a trimeric protein connecting the short fibre to the base-plate, suggesting that the trimerisation motifs of gp11 and gp12 are similar. Repeating sequence motifs suggest that the N-terminal beta-structure extends further towards the N terminus and is conserved in the long tail fibre proteins gp34 and gp37.
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(as it appears on PubMed at http://www.pubmed.gov), where 11743729 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11743729}}
==About this Structure==
==About this Structure==
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[[Category: Fibrous protein]]
[[Category: Fibrous protein]]
[[Category: Gene product 12]]
[[Category: Gene product 12]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:30:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:43:27 2008''

Revision as of 03:43, 1 July 2008

Template:STRUCTURE 1h6w

CRYSTAL STRUCTURE OF A HEAT-AND PROTEASE-STABLE FRAGMENT OF THE BACTERIOPHAGE T4 SHORT FIBRE

Template:ABSTRACT PUBMED 11743729

About this Structure

1H6W is a Protein complex structure of sequences from Enterobacteria phage t4. Full crystallographic information is available from OCA.

Reference

Crystal structure of a heat and protease-stable part of the bacteriophage T4 short tail fibre., van Raaij MJ, Schoehn G, Burda MR, Miller S, J Mol Biol. 2001 Dec 14;314(5):1137-46. PMID:11743729

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