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3pdx

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Current revision (09:52, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3pdx' size='340' side='right'caption='[[3pdx]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
<StructureSection load='3pdx' size='340' side='right'caption='[[3pdx]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3pdx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PDX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PDX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3pdx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PDX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PDX FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.91&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tat ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Tyrosine_transaminase Tyrosine transaminase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.5 2.6.1.5] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pdx OCA], [https://pdbe.org/3pdx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pdx RCSB], [https://www.ebi.ac.uk/pdbsum/3pdx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pdx ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pdx OCA], [https://pdbe.org/3pdx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pdx RCSB], [https://www.ebi.ac.uk/pdbsum/3pdx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pdx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ATTY_MOUSE ATTY_MOUSE]] Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity for phenylalanine.
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[https://www.uniprot.org/uniprot/ATTY_MOUSE ATTY_MOUSE] Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity for phenylalanine.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Tyrosine transaminase]]
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[[Category: Bevan DR]]
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[[Category: Bevan, D R]]
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[[Category: Han Q]]
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[[Category: Han, Q]]
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[[Category: Lemkul JA]]
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[[Category: Lemkul, J A]]
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[[Category: Li J]]
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[[Category: Li, J]]
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[[Category: Mehere PV]]
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[[Category: Mehere, P V]]
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[[Category: Robinson H]]
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[[Category: Robinson, H]]
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[[Category: Alpha/bata protein]]
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[[Category: Aminotransferase]]
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[[Category: Plp-binding]]
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[[Category: Transferase]]
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Current revision

Crystal structural of mouse tyrosine aminotransferase

PDB ID 3pdx

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OCA

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