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7um3

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'''Unreleased structure'''
 
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The entry 7um3 is ON HOLD until Paper Publication
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==Crystal structure of a Fab in complex with a peptide derived from the LAG-3 D1 domain loop insertion==
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<StructureSection load='7um3' size='340' side='right'caption='[[7um3]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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Authors: Zorn, J.A., Lee, P.S., Rajpal, A., Strop, P.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7um3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UM3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UM3 FirstGlance]. <br>
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Description: Crystal structure of a Fab in complex with a peptide derived from the LAG-3 D1 domain loop insertion
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7um3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7um3 OCA], [https://pdbe.org/7um3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7um3 RCSB], [https://www.ebi.ac.uk/pdbsum/7um3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7um3 ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Strop, P]]
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== Function ==
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[[Category: Rajpal, A]]
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[[https://www.uniprot.org/uniprot/LAG3_HUMAN LAG3_HUMAN]] Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648). Delivers inhibitory signals upon binding to ligands, such as FGL1 (By similarity). FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (By similarity). Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1 (By similarity). Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648). Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function (By similarity). Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation (By similarity). Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear (PubMed:8647185).[UniProtKB:Q61790]<ref>PMID:20421648</ref> <ref>PMID:7805750</ref> <ref>PMID:8647185</ref> May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response.[UniProtKB:Q61790]
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[[Category: Lee, P.S]]
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== References ==
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[[Category: Zorn, J.A]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Lee PS]]
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[[Category: Rajpal A]]
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[[Category: Strop P]]
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[[Category: Zorn JA]]

Revision as of 16:37, 7 September 2022

Crystal structure of a Fab in complex with a peptide derived from the LAG-3 D1 domain loop insertion

PDB ID 7um3

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