7zwa

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'''Unreleased structure'''
 
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The entry 7zwa is ON HOLD until Paper Publication
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==CryoEM structure of Ku heterodimer bound to DNA and PAXX==
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<StructureSection load='7zwa' size='340' side='right'caption='[[7zwa]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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Authors: Hardwick, S.W., Kefala-Stavridi, A., Chirgadze, D.Y., Blundell, T.L., Chaplin, A.K.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7zwa]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZWA FirstGlance]. <br>
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Description: CryoEM structure of Ku heterodimer bound to DNA and PAXX
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zwa OCA], [https://pdbe.org/7zwa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zwa RCSB], [https://www.ebi.ac.uk/pdbsum/7zwa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zwa ProSAT]</span></td></tr>
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[[Category: Blundell, T.L]]
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</table>
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[[Category: Chirgadze, D.Y]]
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== Function ==
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[[Category: Chaplin, A.K]]
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[https://www.uniprot.org/uniprot/XRCC5_HUMAN XRCC5_HUMAN] Single stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NAA15, the XRCC5/6 dimer binds to the osteocalcin promoter and activates osteocalcin expression. The XRCC5/6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription.<ref>PMID:7957065</ref> <ref>PMID:8621488</ref> <ref>PMID:12145306</ref> <ref>PMID:20383123</ref>
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[[Category: Hardwick, S.W]]
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== References ==
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[[Category: Kefala-Stavridi, A]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Blundell TL]]
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[[Category: Chaplin AK]]
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[[Category: Chirgadze DY]]
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[[Category: Hardwick SW]]
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[[Category: Kefala-Stavridi A]]

Revision as of 05:36, 31 May 2023

CryoEM structure of Ku heterodimer bound to DNA and PAXX

PDB ID 7zwa

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