3q2e

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Current revision (17:09, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3q2e' size='340' side='right'caption='[[3q2e]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
<StructureSection load='3q2e' size='340' side='right'caption='[[3q2e]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3q2e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q2E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q2E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3q2e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q2E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q2E FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRWD1, C21orf107, WDR9 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q2e OCA], [https://pdbe.org/3q2e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q2e RCSB], [https://www.ebi.ac.uk/pdbsum/3q2e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q2e ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q2e OCA], [https://pdbe.org/3q2e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q2e RCSB], [https://www.ebi.ac.uk/pdbsum/3q2e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q2e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/BRWD1_HUMAN BRWD1_HUMAN]] May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.<ref>PMID:21834987</ref>
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[https://www.uniprot.org/uniprot/BRWD1_HUMAN BRWD1_HUMAN] May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.<ref>PMID:21834987</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Delft, F Von]]
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[[Category: Edwards A]]
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[[Category: Edwards, A]]
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[[Category: Felletar I]]
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[[Category: Felletar, I]]
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[[Category: Filippakopoulos P]]
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[[Category: Filippakopoulos, P]]
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[[Category: Gileadi O]]
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[[Category: Gileadi, O]]
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[[Category: Keates T]]
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[[Category: Keates, T]]
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[[Category: Knapp S]]
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[[Category: Knapp, S]]
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[[Category: Krojer T]]
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[[Category: Krojer, T]]
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[[Category: Muniz J]]
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[[Category: Muniz, J]]
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[[Category: Picaud S]]
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[[Category: Picaud, S]]
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[[Category: Von Delft F]]
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[[Category: Structural genomic]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J]]
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[[Category: Apoptosis]]
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[[Category: Bromodomain]]
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[[Category: Cell cycle progression]]
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[[Category: Down syndrome region-2 on chromosome 21]]
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[[Category: Gene regulation]]
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[[Category: Sgc]]
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[[Category: Signal transduction]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of the second bromodomain of human bromodomain and WD repeat-containing protein 1 isoform A (WDR9)

PDB ID 3q2e

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OCA

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