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3q2o
From Proteopedia
(Difference between revisions)
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<StructureSection load='3q2o' size='340' side='right'caption='[[3q2o]], [[Resolution|resolution]] 1.96Å' scene=''> | <StructureSection load='3q2o' size='340' side='right'caption='[[3q2o]], [[Resolution|resolution]] 1.96Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3q2o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3q2o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis_str._A0248 Bacillus anthracis str. A0248]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q2O FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q2o OCA], [https://pdbe.org/3q2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q2o RCSB], [https://www.ebi.ac.uk/pdbsum/3q2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q2o ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q2o OCA], [https://pdbe.org/3q2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q2o RCSB], [https://www.ebi.ac.uk/pdbsum/3q2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q2o ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | The apo structure of N5-carboxyaminoimidazole ribonucleotide synthase (PurK) from Bacillus anthracis (baPurK) with Mg2+ in the active site is reported at 1.96 A resolution. PurK is an enzyme in the purine-biosynthetic pathway, unique to prokaryotes, that converts 5-aminoimidazole ribonucleotide to N5-carboxyaminoimidazole ribonucleotide and has been suggested as a potential antimicrobial drug target. Two interesting features of baPurK are a flexible B-loop (residues 149/150-157) that is in close contact with the active site and the binding of Mg2+ to the active site without additional ligands. | ||
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| - | Structure of N5-carboxyaminoimidazole ribonucleotide synthase (PurK) from Bacillus anthracis.,Tuntland ML, Johnson ME, Fung LW, Santarsiero BD Acta Crystallogr D Biol Crystallogr. 2011 Oct;67(Pt 10):870-4. Epub 2011, Sep 8. PMID:21931218<ref>PMID:21931218</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 3q2o" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[Phosphoribosylaminoimidazole carboxylase 3D structures|Phosphoribosylaminoimidazole carboxylase 3D structures]] | *[[Phosphoribosylaminoimidazole carboxylase 3D structures|Phosphoribosylaminoimidazole carboxylase 3D structures]] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Bacillus anthracis str. A0248]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | + | [[Category: Fung LW]] | |
| - | [[Category: Fung | + | [[Category: Johnson ME]] |
| - | [[Category: Johnson | + | [[Category: Santarsiero BD]] |
| - | [[Category: Santarsiero | + | [[Category: Tuntland ML]] |
| - | [[Category: Tuntland | + | |
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Current revision
Crystal Structure of purK: N5-carboxyaminoimidazole ribonucleotide synthetase
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