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3q30

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Current revision (17:09, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3q30' size='340' side='right'caption='[[3q30]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3q30' size='340' side='right'caption='[[3q30]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3q30]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q30 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q30 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3q30]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q30 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q30 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D61:(2R,3R)-2-(CARBOXYMETHOXY)-4-{[5-(NAPHTHALEN-2-YL)PENTYL]AMINO}-3-{[5-(NAPHTHALEN-2-YL)PENTYL]OXY}-4-OXOBUTANOIC+ACID'>D61</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3q2z|3q2z]], [[3asx|3asx]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D61:(2R,3R)-2-(CARBOXYMETHOXY)-4-{[5-(NAPHTHALEN-2-YL)PENTYL]AMINO}-3-{[5-(NAPHTHALEN-2-YL)PENTYL]OXY}-4-OXOBUTANOIC+ACID'>D61</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FDFT1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q30 OCA], [https://pdbe.org/3q30 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q30 RCSB], [https://www.ebi.ac.uk/pdbsum/3q30 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q30 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q30 OCA], [https://pdbe.org/3q30 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q30 RCSB], [https://www.ebi.ac.uk/pdbsum/3q30 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q30 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FDFT_HUMAN FDFT_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Squalene synthase]]
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[[Category: Higashihashi N]]
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[[Category: Higashihashi, N]]
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[[Category: Ichikawa M]]
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[[Category: Ichikawa, M]]
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[[Category: Itoh M]]
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[[Category: Itoh, M]]
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[[Category: Katakura S]]
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[[Category: Katakura, S]]
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[[Category: Shimizu H]]
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[[Category: Shimizu, H]]
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[[Category: Sugita K]]
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[[Category: Sugita, K]]
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[[Category: Suzuki M]]
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[[Category: Suzuki, M]]
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[[Category: Usui H]]
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[[Category: Usui, H]]
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[[Category: Yamazaki K]]
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[[Category: Yamazaki, K]]
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[[Category: Yokomizo A]]
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[[Category: Yokomizo, A]]
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[[Category: Isoprene biosynthesis]]
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[[Category: Lipid synthesis]]
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[[Category: Multifunctional enzyme]]
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[[Category: Oxidoreductase]]
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[[Category: Steroid biosynthesis]]
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[[Category: Sterol biosynthesis]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Human Squalene synthase in complex with (2R,3R)-2-Carboxymethoxy-3-[5-(2-naphthalenyl)pentyl]aminocarbonyl-3-[5-(2-naphthalenyl)pentyloxy]propionic acid

PDB ID 3q30

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OCA

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