3q5i

Structural highlights

Function

CDPK1_PLABA Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase (By similarity). During the liver stage, involved in sporozoite motility and thus in sporozoite invasion of host hepatocytes, probably together with CDPK4 and CDPK5 (PubMed:32866196). In the mosquito midgut and during the last stage of male gamete exflagellation, may play a role in the rupture of the host erythrocyte membrane (PubMed:22817984). In the mosquito midgut, required for the differentiation of the zygote into the ookinete by promoting the translational activation of a subset of repressed mRNAs; these mRNAs are kept repressed in the zygote by the DOZI- or CITH-containing mRNP complexes (PubMed:22817984, PubMed:24265753). Dispensable during the asexual blood stage (PubMed:24265753).[UniProtKB:P62344]^{[1] [2] [3]}

References

1. ↑ Sebastian S, Brochet M, Collins MO, Schwach F, Jones ML, Goulding D, Rayner JC, Choudhary JS, Billker O. A Plasmodium calcium-dependent protein kinase controls zygote development and transmission by translationally activating repressed mRNAs. Cell Host Microbe. 2012 Jul 19;12(1):9-19. PMID:22817984 doi:10.1016/j.chom.2012.05.014
2. ↑ Jebiwott S, Govindaswamy K, Mbugua A, Bhanot P. Plasmodium berghei calcium dependent protein kinase 1 is not required for host cell invasion. PLoS One. 2013 Nov 12;8(11):e79171. PMID:24265753 doi:10.1371/journal.pone.0079171
3. ↑ Govindasamy K, Bhanot P. Overlapping and distinct roles of CDPK family members in the pre-erythrocytic stages of the rodent malaria parasite, Plasmodium berghei. PLoS Pathog. 2020 Aug 31;16(8):e1008131. PMID:32866196 doi:10.1371/journal.ppat.1008131