7xpz

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'''Unreleased structure'''
 
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The entry 7xpz is ON HOLD until Paper Publication
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==Structure of Apo-hSLC19A1==
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<StructureSection load='7xpz' size='340' side='right'caption='[[7xpz]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7xpz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XPZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XPZ FirstGlance]. <br>
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Description:
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xpz OCA], [https://pdbe.org/7xpz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xpz RCSB], [https://www.ebi.ac.uk/pdbsum/7xpz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xpz ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/S19A1_HUMAN S19A1_HUMAN] Methotrexate dose selection. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/S19A1_HUMAN S19A1_HUMAN] Antiporter that mediates the import of reduced folates or a subset of cyclic dinucleotides, driven by the export of organic anions (PubMed:7826387, PubMed:9041240, PubMed:10787414, PubMed:15337749, PubMed:16115875, PubMed:22554803, PubMed:31511694, PubMed:31126740, PubMed:32276275). Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates (PubMed:22554803, PubMed:31511694, PubMed:31126740). Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate (PubMed:10787414, PubMed:14609557, PubMed:22554803). Also able to mediate the import of antifolate drug methotrexate (PubMed:7615551, PubMed:7641195, PubMed:9767079, PubMed:22554803). Also acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP, thus playing a role in triggering larger immune responses (PubMed:31511694, PubMed:31126740). 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity (PubMed:22554803).<ref>PMID:10787414</ref> <ref>PMID:14609557</ref> <ref>PMID:15337749</ref> <ref>PMID:16115875</ref> <ref>PMID:22554803</ref> <ref>PMID:31126740</ref> <ref>PMID:31511694</ref> <ref>PMID:32276275</ref> <ref>PMID:7615551</ref> <ref>PMID:7641195</ref> <ref>PMID:7826387</ref> <ref>PMID:9041240</ref> <ref>PMID:9767079</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Gao A]]
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[[Category: Gao P]]
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[[Category: Sun PP]]
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[[Category: Zhang LG]]
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[[Category: Zhang QX]]
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[[Category: Zhang XY]]
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[[Category: Zhu YL]]

Revision as of 20:28, 16 November 2022

Structure of Apo-hSLC19A1

PDB ID 7xpz

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OCA

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